Ahmad Mani-Varnosfaderani

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The present study was designed to search for metabolic biomarkers and their correlation with serum zinc in Crohn's disease patients. Crohn's disease (CD) is a form of inflammatory bowel disease that may affect any part of the gastrointestinal tract and can be difficult to diagnose using the clinical tests. Thus, introduction of a novel diagnostic method(More)
Bayesian regularised genetic neural network (BRGNN) has been used for modelling the inhibition activity of 141 biphenylalanine derivatives as integrin antagonists. Three local pattern search (PS) methods, simulated annealing and threshold acceptance were combined with BRGNN in the form of a hybrid genetic algorithm (HGA). The results obtained revealed that(More)
In the current work, the relationship between the structure and activity of a series of novel thiazolidine-4-carboxylic acid derivatives as potent influenza virus neuraminidase inhibitors was studied using docking, molecular dynamics (MD) simulations, and QSAR analysis. A 7,000 ps MD simulation in a cubic water box were employed to build 3D structure of the(More)
The vascular endothelial growth factor receptor (VEGFR2) is an attractive target for the development of novel anticancer agents. Molecular docking and quantitative structure–activity relationship (QSAR) were used to investigate how inhibitors’ chemical structures relate to the inhibitory activities. The molecular docking studies show that at least one(More)
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