Ahmad Jalili

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Neurons are exposed to damaging stimuli that can trigger cell death and subsequently cause serious neurological disorders. Therefore, it is important to define defense mechanisms that can be activated in response to damage to reduce neuronal loss. Here we report that cisplatin (CPDD), a neurotoxic anticancer drug that damages DNA, triggered apoptosis and(More)
Resistance to BRAF(V600E) inhibitors is associated with reactivation of mitogen-activated protein kinase (MAPK) signaling at different levels in melanoma. To identify downstream effectors of MAPK signaling that could be used as potential additional therapeutic targets for BRAF(V600E) inhibitors, we used hTERT/CDK4R24C/p53DD-immortalized primary human(More)
Melanoma is one of the most aggressive cancers and its incidence is increasing worldwide. So far there are no curable therapies especially after metastasis. Due to frequent mutations in members of the mitogen-activated protein kinase (MAPK) signaling pathway, this pathway is constitutively active in melanoma. It has been shown that the SONIC HEDGEHOG(More)
Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that can promote antitumor immunity when pulsed with tumor antigens and then matured by stimulatory agents. Despite apparent progress in DC-based cancer immunotherapy, some discrepancies were reported in generating potent DCs. Listeria monocytogenes as an intracellular microorganism is able to(More)
Copyright © 2016 Ieva Saulite et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Skin cancer incidence rates show a tendency for continuous increase. Along with this rise, cutaneous(More)
Wireless Sensor Networks (WSNs) have been applied in variety of industrial, medical and military applications. There are many routing protocols proposed for WSNs to deal with challenges such as energy depletion and latency of data transmission from nodes to base station. Recently, researchers have focused on Chain-based protocols. CCBRP (Chain-Chain Based(More)
We report a case of rapidly progressing poststreptococ-cal scleredema adultorum Buschke (SAB) that successfully responded to treatment with intravenous immuno-globulins (IVIGs). A 38-year-old white woman presented with a 3-week history of a rapidly progressing symmetrical induration of the skin starting on the upper trunk area and spreading over the(More)
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