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Keywords: Fed-batch fermentation process Penicillin production Model predictive control Nonlinear model LoLiMoT a b s t r a c t Bioprocesses are involved in producing different pharmaceutical products. Complicated dynamics, non-linearity and non-stationarity make controlling them a very delicate task. The main control goal is to get a pure product with a(More)
OBJECTIVE (1) To determine the brain connectivity pattern associated with clinical rigidity scores in Parkinson's disease (PD) and (2) to determine the relation between clinically assessed rigidity and quantitative metrics of motor performance. BACKGROUND Rigidity, the resistance to passive movement, is exacerbated in PD by asking the subject to move the(More)
In this paper, the performance of image filtering using the Hilbert Matrix and its inverse is studied first and according to its results, a new edge enhancement and embossing algorithm is proposed. Most of the Laplacian and Sobel-based edge detection methods use small masks. The algorithm suggested here not only enhances and sharpens the edges of the image,(More)
— Parkinson's disease (PD) is a neurodegenerative disorder that impairs motor skills, speech, and other voluntary movement, and may be associated with cognitive inflexibility. Fourteen PD subjects (both on and off medication) and 10 normal subjects performed a manual pursuit tracking task, in which the dynamics of the task suddenly change without explicit(More)
Introduction: Detailed assessment of behavioral disorders is of high importance, especially in preschool children. The present study aimed to compare the prevalence of behavioral disorders between preschool boys and girls and suggestion about strategies for reduction these problems. Materials and Methods: Statistical community of this descriptive study was(More)
Bioprocesses, which are involved in producing different antibiotics and other pharmaceutical products, may be conveniently classified according to the mode chosen for the process: either batch, fed-batch or continuous. From the control engineer's viewpoint it is the fed-batch processes, however, which present the greatest challenge to get a pure product(More)
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