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A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge
The recombinant virus VC2 is constructed that contains specific mutations in gK and the membrane protein UL20 preventing virus entry into axonal compartments of neurons, while allowing efficient replication in cell culture, unlike the gK-null virus, which has a major defect in virus replication and spread. Expand
Antimicrobial susceptibility patterns of Rhodococcus equi from necropsied foals with rhodococcosis.
Mainstay therapy for rhodococcosis in foals is the combination of rifampicin and a macrolide. While emergence of resistance to rifampicin and macrolides has been reported, studies demonstrating theExpand
A Herpes Simplex Virus 1 (McKrae) Mutant Lacking the Glycoprotein K Gene Is Unable To Infect via Neuronal Axons and Egress from Neuronal Cell Bodies
A recombinant virus with the gK gene deleted in the highly virulent ocular HSV-1 strain McKrae was constructed and suggested that gK is a critical determinant for neuronal infection and transmission. Expand
A Replication Competent HSV-1(McKrae) with a Mutation in the Amino-terminus of Glycoprotein K (gK) is Unable to Infect Mouse Trigeminal Ganglia after Cornea Infection
The results show that the amino terminus of gK is essential for neuroinvasiveness and acute herpes keratitis in the mouse eye model, and it is likely thatgK is involved in efficient infection of axonal termini, since mouse eye scarification provided a direct access to the high density of neurons innervating mouse corneas. Expand
Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons
It is shown that a predicted β-sheet domain, which is conserved among alphaherpesviruses, functions in HSV-1 entry into neuronal axons, suggesting that it may serve similar functions for other herpesviruses. Expand
Bilateral Seminoma With Hepatic Metastasis in a Cockatiel (Nymphicus hollandicus)
An 18-year-old, intact male cockatiel presented with a clinical history of dyspnea, lethargy, and reluctance to perch and was euthanatized with the first case of a metastatic bilateral testicular seminoma reported in a cockatiels. Expand
Ulcerative, granulomatous glossitis and enteritis caused by Rhodococcus equi in a heifer
An atypical and unusual clinical presentation of R. equi infection in cattle is reported, which has zoonotic potential and lacks the circular plasmids vapA and vapB that are associated with virulence in horses and swine. Expand
Functional Hierarchy of Herpes Simplex Virus Type-1 Membrane Proteins in Corneal Infection and Virus Transmission to Ganglionic Neurons
The results show that gK plays the most important role among gM, gE and UL11 in corneal and ganglionic infection in the mouse eye model. Expand
An Integrated AHP-PROMETHEE Method for Selecting the most Suitable Ethylene Propylene Diene Termonomer
This paper considers the problem of selecting the most appropriate ethylene propylene diene monomer (EPDM), which is a polyolefin with a variety of usages in different areas. The metalloceneExpand
Therapy resistant septic enteritis due to a jejunal malformation in a 5-day-old Thoroughbred colt.
Although rare, intestinal malformations should be considered in neonatal foals with clinical signs resembling enteritis after a 5-day-old Thoroughbred colt was presented with profuse watery diarrhea, hypovolemic shock, and a patent urachus. Expand