Agnieszka Zmysłowska

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BACKGROUND In some patients the ketoacidosis at the onset of type 1 diabetes has been observed. AIM The aim of this study was to investigate an effect of the clinical, genetic, immunological and metabolic parameters on the occurrence of ketoacidosis at the clinical onset of the disease. MATERIAL AND METHODS 106 children with type 1 diabetes, aged(More)
INTRODUCTION Despite the progress in diagnosis and treatment of type 1 diabetes, diabetic ketoacidosis (DKA) is still a serious clinical problem. The aim of the study was too describe the epidemiology and clinical characteristic of DKA in children and adolescents with type 1 diabetes. MATERIAL AND METHODS Medical records of 650 patients with type 1(More)
AIMS To determine (i) whether insulin preparations produced by three companies induce the same immune responses in insulin-naïve children with type 1 diabetes (T1DM); (ii) if switching from human insulin to rapid-acting insulin analogs influences this immune response; and (iii) if different insulin brands produce different clinical results during the first(More)
INTRODUCTION Wolfram syndrome (WFS) is the most frequent syndromic form of monogenic diabetes coexisting with optic atrophy and many other disorders. The aim of this study was to estimate the prevalence of Wolfram syndrome among children with diabetes in Poland. MATERIAL AND METHODS These calculations were performed among Polish diabetic children, aged(More)
Wolfram syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness), is a rare autosomal recessive syndrome (1/770,000 in the United Kingdom), characterised by juvenile onset of diabetes mellitus, optic nerve atrophy, diabetes insipidus, sensorineural deafness, renal tract and neurological abnormalities, and(More)
The most frequent form of diabetes in the childhood is type 1 diabetes. Moreover, the rare forms of diabetes have been also identified in children. Besides of neonatal diabetes caused by the mutations in KCNJ11, SUR1 and GCK genes, other forms of monogenic diabetes are associated with different chronic disorders. These rare forms of syndromic diabetes are(More)
Clinical symptoms of type 1 diabetes are preceded by a long period of prediabetes stage characterised by anti-islet antibodies occurrence as well as insulin and C-peptide secretion disturbances. The aim of this study was to define the prognostic value of type 1 diabetes antiislet humoral markers (ICA, anti-GAD, anti-IA2 and IAA) and to find out thresholds(More)
Kwasica ketonowa (DKA) jest najczęstszym ostrym powikłaniem cukrzycy typu 1 (T1DM) u dzieci. Spośród wszystkich ostrych powikłań cukrzycy typu 1 kwasica ketonowa związana jest z największym ryzykiem wystąpienia obrzęku mózgu. Celem pracy było przedstawienie stanu wiedzy dotyczącego oceny ryzyka wystąpienia obrzęku mózgu u pacjentów z kwasicą ketonową w(More)
Urinary tract infection (UTI) in infants and babies is still a challenging problem. The aim of the study was the clinical analysis of children under three years of age with UTI, hospitalised in The Department of Paediatrics, Medical University of Lodz in 2000-2001. The study included 91 children (45 girls and 46 boys), aged 1-36 months; 10 months on the(More)
Type 1 diabetes mellitus is caused by autoimmune destruction of beta cells of the Langerhans islets. At the early stage of the disease in some patients clinical remission is observed. Until now no unequivocal criteria of complete or partial remission in diabetes have been established. In order to better define this phenomenon, individual, metabolic and(More)