Agnieszka Szynol

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21 Running title: Llama antibody fragments that neutralize HIV-1 22 Abstract word count: 243 Text word count: 7226 23 2 ABSTRACT 1 Members of the Camelidae family produce immunoglobulins devoid of light chains. We have 2 characterized variable domains of these heavy-chain antibodies, the VHH, from llamas 3 immunized with HIV-1 envelope protein gp120 in(More)
Many of the neutralising antibodies, isolated to date, display limited activities against the globally most prevalent HIV-1 subtypes A and C. Therefore, those subtypes are considered to be an important target for antibody-based therapy. Variable domains of llama heavy chain antibodies (VHH) have some superior properties compared with classical antibodies.(More)
Recently, we described llama antibody fragments (VHH) that can neutralize human immunodeficiency virus, type 1 (HIV-1). These VHH were obtained after selective elution of phages carrying an immune library raised against gp120 of HIV-1 subtype B/C CN54 with soluble CD4. We describe here a new, family-specific approach to obtain the largest possible diversity(More)
The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington's disease (HD). Recent studies have reported that RNAi suppression of polyglutamine-expanded huntingtin (mutant HTT) in HD animal models can ameliorate disease phenotypes. A key requirement(More)
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