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1. The experiments described here are addressed at identifying some of the processes underlying arm movements in monkeys. 2. We used three adult monkeys that were trained to point to a target light with the forearm and hold at that position for about 1 s in order to obtain a reward. During the experimental sessions the monkey was seated in a primate chair(More)
The studies reported here are directed toward understanding some of the mechanisms whereby the central nervous system terminates a given phase in a motor sequence and maintains a newly acquired position. In particular, we investigated the extent to which the termination of a centrally initiated head movement in monkeys and the subsequent maintenance of(More)
1. We have investigated the relative contributions of mechanical and reflex mechanisms in generating the forces produced by the neck muscles when loads were unexpectedly applied during centrally programmed head movements in monkeys. These movements, subserved by muscles well endowed with muscle spindles, are part of the coordinated eye-head response to the(More)
The postural adjustment which accompanies single limb movement in the standing cat and dog was analyzed. Four trays equipped with strain gauges were used for measuring the vertical forces exerted by each limb before and during movement performance. Three types of movements were analyzed: flexion movements elicited by motor cortex stimulation, placing(More)
In the present study, detailed information is presented on the hetero-dimerization of the serotonin 5-HT(2A) receptor and the dopamine D(2) receptor. Biophysical approaches (fluorescence spectroscopy as well as fluorescence lifetime microscopy) were used to determine the degree of fluorescence resonance energy transfer (FRET) between cyan and yellow(More)
In these experiments we studied the organization of the neural pattern of activity underlying the achievement and maintenance of final limb position. The examination of the alpha motoneuronal inputs to flexors and extensors acting on the elbow and wrist joints revealed that a change from one posture to another required a modulation of both flexors and(More)
The concept that G protein-coupled receptors (GPCRs) function as oligomers has been widely accepted, however, different methodologies often used to study the phenomenon of GPCR interactions do not allow, as yet, for any generalization as to whether di- or oligomers are formed constitutively or are ligand-promoted. Here, we report on the use of three(More)
A comparative analysis of adjustment of posture for performance of different kinds of local movements (movements elicited by electrical stimulation of the motor cortex; proprioceptive reaction of placing the paw on a support, conditioned lifts of the paw) was made in cats and dogs. The present experimental data were obtained in two laboratories independent(More)