Agnieszka Matłoka

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Photochemical decomposition of two derivatives of 1,4-dihydropyridine (DHP): felodipine (FL) and nimodipine (NM) was studied. Photodegradation of FL and NM was carried out in compliance with the first version of International Conference on Harmonization (ICH) recommendations. Quantitative assessment of photodegradation of the DHP derivatives studied was(More)
The photochemical stability of 2,6,6-trimethyl-3-carbmethoxy-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline (HHQ) derivatives with different substituents on the phenyl ring (-Cl, -NO2, -CF3, -CH3, -OCH3) has been studied. The process of photodegradation was studied by UV spectrophotometry. The rate of photodegradation was found to depend on the type and(More)
Photoproducts of hexahydroquinoline derivatives have been analyzed with gas chromatography electro ionization-mass spectrometry (GC-EI-MS) and high performance chromatography electrospray ionization-mass spectrometry (HPLC-ESI-MS). The study was performed on four HHQ derivatives:(More)
Photodegradation products of hexahydroquinoline derivatives (HHQ) have been analysed with gas chromatography-mass spectrometry (GC-MS). The photodegradation was carried out under the conditions recommended in the first version of the document issued by the International Conference on Harmonization (ICH), currently in force in the studies of photochemical(More)
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