Agnieszka E. Brouns

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The aim of this study was to compare the systemic hemodynamic effects of four commonly used anesthetic regimens in mice that were chronically instrumented for direct and continuous measurements of cardiac output (CO). Mice (CD-1, Swiss, and C57BL6 strains) were instrumented with a transit-time flow probe placed around the ascending aorta for CO measurement.(More)
AIM To identify the initial alterations in myocardial tissue associated with the early signs of diabetic cardiac haemodynamic dysfunction, we monitored changes in cardiac function, structural remodelling and gene expression in hearts of type 2 diabetic db/db mice. METHODS Cardiac dimensions and function were determined echocardiographically at 8, 12, 16(More)
AIMS Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a nuclear receptor regulating cardiac metabolism that also has anti-inflammatory properties. Since the activation of inflammatory signalling pathways is considered to be important in cardiac hypertrophy and fibrosis, it is anticipated that PPARalpha modulates cardiac remodelling.(More)
The aim of this study was to compare the systemic hemodynamic effects of four commonly used anesthetic regimens in mice chronically instrumented for direct and continuous measurements of cardiac output (CO). Mice (CD-1, Swiss and C57Bl6) were instrumented with a transit-time flow probe placed around the ascending aorta for measurement of CO. An arterial(More)
BACKGROUND Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial remodeling and the development of cardiac dysfunction in type 2 diabetic db/db mice. METHODS Thereto, 14-wks-old male db/db mice and non-diabetic db/+ mice received vehicle or angiotensin(More)
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