Agnieszka E. Brouns

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BACKGROUND Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial remodeling and the development of cardiac dysfunction in type 2 diabetic db/db mice. METHODS Thereto, 14-wks-old male db/db mice and non-diabetic db/+ mice received vehicle or angiotensin(More)
The aim of this study was to compare the systemic hemodynamic effects of four commonly used anesthetic regimens in mice chronically instrumented for direct and continuous measurements of cardiac output (CO). Mice (CD-1, Swiss and C57Bl6) were instrumented with a transit-time flow probe placed around the ascending aorta for measurement of CO. An arterial(More)
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