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Structural Organization of the Actin Cytoskeleton at Sites of Clathrin-Mediated Endocytosis

• Agnieszka Collins, Anthony Warrington, Kenneth A. Taylor, Tatyana M Svitkina
• Current Biology
• 2011

BACKGROUND The dynamic actin cytoskeleton plays an important role in clathrin-mediated endocytosis (CME). However, its exact functions remain uncertain as a result of a lack of high-resolution… (More)

Mechanism of actin filament bundling by fascin.

• Silvia Jansen, Agnieszka Collins, Changsong Yang, Grzegorz Rebowski, Tatyana M Svitkina, Roberto A Dominguez
• The Journal of biological chemistry
• 2011

Fascin is the main actin filament bundling protein in filopodia. Because of the important role filopodia play in cell migration, fascin is emerging as a major target for cancer drug discovery.… (More)

Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics.

• Silvia Jansen, Agnieszka Collins, Leslie Golden, Olga Sokolova, Bruce L. Goode
• The Journal of biological chemistry
• 2014

Srv2/CAP is a conserved actin-binding protein with important roles in driving cellular actin dynamics in diverse animal, fungal, and plant species. However, there have been conflicting reports about… (More)

Single-molecule imaging of a three-component ordered actin disassembly mechanism

• Silvia Jansen, Agnieszka Collins, Samantha M. Chin, Casey A. Ydenberg, Jeff Gelles, Bruce L. Goode
• Nature communications
• 2015

The mechanisms by which cells destabilize and rapidly disassemble filamentous actin networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated in this process. Here using… (More)

High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP

• Adam B. Johnston, Agnieszka Collins, Bruce L. Goode
• Nature Cell Biology
• 2015

Purified actin filaments depolymerize slowly, and cytosolic conditions strongly favour actin assembly over disassembly, which has left our understanding of how actin filaments are rapidly turned over… (More)

Divalent cation-induced cluster formation by polyphosphoinositides in model membranes.

• Yu-Hsiu Wang, Agnieszka Collins, +4 authors Paul A. Janmey
• Journal of the American Chemical Society
• 2012

Polyphosphoinositides (PPIs) and in particular phosphatidylinositol-(4,5)-bisphosphate (PI4,5P2), control many cellular events and bind with variable levels of specificity to hundreds of… (More)

High Speed Depolymerization at Actin Filament Ends Jointly Catalyzed by Twinfilin and Srv2/CAP

• Adam B. Johnston, Agnieszka Collins, Bruce L. Goode
• 2015

The Formin Daam1 and Fascin Directly Collaborate to Promote Filopodia Formation

• Richa Jaiswal, Dennis Breitsprecher, Agnieszka Collins, Ivan R Corrêa, Ming-Qun Xu, Bruce L. Goode
• Current Biology
• 2013

Filopodia are slender cellular protrusions that dynamically extend and retract to facilitate directional cell migration, pathogen sensing, and cell-cell adhesion. Each filopodium contains a rigid and… (More)

Structural studies on maturing actin filaments.

• Agnieszka Collins, Renjian Huang, Mikkel Herholdt Jensen, Jeffrey R. Moore, William Lehman, C L Albert Wang
• Bioarchitecture
• 2011

We have previously reported that actin undergoes a conformational transition (which we named "maturation") during polymerization, and that the actin-binding protein, caldesmon (CaD), when added at an… (More)

A novel role for WAVE1 in controlling actin network growth rate and architecture

• Meredith O. Sweeney, Agnieszka Collins, Shae B. Padrick, Bruce L. Goode
• Molecular biology of the cell
• 2015

Branched actin filament networks in cells are assembled through the combined activities of Arp2/3 complex and different WASP/WAVE proteins. Here we used TIRF and electron microscopy to directly… (More)

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