Agnes M. Herzberg

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Three properties of interest in bioavailability studies using compartmental models are the area under the concentration curve, the maximum concentration, and the time to maximum concentration. Methods are described for finding designs that minimize the variance of the estimates of these quantities in such a model. These methods use prior information. Both(More)
T he Sudoku puzzle has become a very popular puzzle that many newspapers carry as a daily feature. The puzzle consists of a 9 × 9 grid in which some of the entries of the grid have a number from 1 to 9. One is then required to complete the grid in such a way that every row, every column, and every one of the nine 3 × 3 sub-grids contain the digits from 1 to(More)
Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one,(More)
The construction of optimal experimental designs for regression models requires knowledge of the information matrix of a single observation. The latter can be found if the elemental information matrices corresponding to the distribution of the response are known. We present tables of elemental information matrices for distributions that are often used in(More)
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