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Differences in binding and effector functions between classes of TNF antagonists.

• Taruna Arora, Rupa Padaki, +5 authors Tadahiko Kohno
• Cytokine
• 2009

There are currently two Food and Drug Administration-approved classes of biologic agents that target tumor necrosis factor-alpha (TNF-alpha): anti-TNF monoclonal antibodies (mAbs) (adalimumab and… (More)

In vitro assembly of alphavirus cores by using nucleocapsid protein expressed in Escherichia coli.

• Timothy L. Tellinghuisen, Agnes E Hamburger, Bonnie R. Fisher, R Ostendorp, Richard J. Kuhn
• Journal of virology
• 1999

The production of the alphavirus virion is a multistep event requiring the assembly of the nucleocapsid core in the cytoplasm and the maturation of the glycoproteins in the endoplasmic reticulum and… (More)

Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae.

• Rensheng Luo, Beth Mann, +9 authors Richard W. Kriwacki
• The EMBO journal
• 2005

Streptococcus pneumoniae (pneumococcus) remains a significant health threat worldwide, especially to the young and old. While some of the biomolecules involved in pneumococcal pathogenesis are known… (More)

Crystal structure of the S.cerevisiae exocyst component Exo70p.

• Zsuzsa A Hamburger, Agnes E Hamburger, Anthony P. West, William I Weis
• Journal of molecular biology
• 2006

The exocyst is an evolutionarily conserved multiprotein complex required for the targeting and docking of post-Golgi vesicles to the plasma membrane. Through its interactions with a variety of… (More)

Steric accessibility of the HIV-1 gp41 N-trimer region.

• Agnes E Hamburger, Sunghwan Kim, Brett Welch, Michael S Kay
• The Journal of biological chemistry
• 2005

During human immunodeficiency virus entry, gp41 undergoes a series of conformational changes that induce membrane fusion. Immediately prior to fusion, gp41 exists in a prehairpin intermediate in… (More)

Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains.

• Agnes E Hamburger, Anthony P. West, Zsuzsa A Hamburger, Peter Hamburger, Pamela J. Bjorkman
• Journal of molecular biology
• 2005

Ferritins are iron storage proteins made of 24 subunits forming a hollow spherical shell. Vertebrate ferritins contain varying ratios of heavy (H) and light (L) chains; however, known ferritin… (More)

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

• Richard Smith, Amy Duguay, +15 authors Yang Li
• PloS one
• 2013

The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer… (More)

Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor.

• Agnes E Hamburger, Anthony P. West, Pamela J. Bjorkman
• Structure
• 2004

The polymeric immunoglobulin receptor (pIgR) is a type I transmembrane protein that delivers dimeric IgA (dIgA) and pentameric IgM to mucosal secretions. Here, we report the 1.9 A resolution X-ray… (More)

Structural insights into antibody-mediated mucosal immunity.

• Agnes E Hamburger, Pamela J. Bjorkman, Andrew B Herr
• Current topics in microbiology and immunology
• 2006

The mucosal regions of the body are responsible for defense against environmental pathogens. Particularly in the lumen of the gut, antibody-mediated immune responses are critical for preventing… (More)

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