Aghdas Dehghani

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INTRODUCTION Gentamicin (GM) as an antibiotic is used in clinic. However, its administration is limited by side effects such as nephrotoxicity. Herbal extracts could be used in therapeutic approaches. OBJECTIVES The present study was planned to investigate whether pomegranate flower extract (PFE) could ameliorate GM-induced renal toxicity in male rats. (More)
Background. The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF) response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779) and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Methods. Ovariectomized Wistar rats received(More)
BACKGROUND Cisplatin (CP) is an effective chemotherapeutic drug used in the clinic, which is accompanied with nephrotoxicity. CP may also disturb hemodynamics of the circulation system. We have tested the role of CP in mean arterial pressure (MAP) response to graded angiotensin (Ang) II infusion in rats. MATERIALS AND METHODS Male and female rats were(More)
BACKGROUND Chemotherapy with cisplatin (CP) is accompanied with nephrotoxicity. OBJECTIVES In the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. MATERIALS AND METHODS Thirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in groups 1 to 3(More)
Introduction: Jugulans regia (Jugulandaceae), Astragaus hamosus (Papilionaceae), Crocus pallasii subsp. haussknechtii boiss. (Iridaceae) and Cassia angustifolia Vahl. (Caesalpinaceae) have been suggested as antiepileptic remedies in traditional medicine of Iran. The possible anticonvulsant effect of the hydroalcoholic extract of the leaves of J. regia,(More)
The angiotensin 1-7 (Ang 1-7), is abundantly produced in kidneys and antagonizes the function of angiotensin II through Mas receptor (MasR) or other unknown mechanisms. In the current study, the role of MasR and steroid hormone estrogen on renal blood flow response to Ang 1-7 administration was investigated in ovariectomized (OV) female rats. OV female(More)
Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been(More)
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