Agata Białońska

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Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14alpha-hydroxyandrost-4-en-3,17-dione (in over 75%(More)
The course of transformation of DHEA, androstenediol and epiandrosterone in Mortierella isabellina AM212 culture was investigated. The mentioned substrates underwent effective hydroxylation; 5-ene substrates--DHEA and androstenediol--were transformed into a mixture of 7α- and 7β- allyl alcohols, while epiandrosterone was converted into 7α- (mainly), 11α-(More)
This paper demonstrates for the first time transformation of a series of 17-oxo steroidal substrates (epiandrosterone, dehydroepiandrosterone, androstenedione) by the most frequently used whole cell biocatalyst, Beauveria bassiana, to 11α-hydroxy-17a-oxa-d-homo-androst-17-one products, in the following sequence of reactions: 11α-hydroxylation and subsequent(More)
Five optically active and sixteen racemic lactones (nine of them new) of bicyclo[4.3.0]nonane structure were synthesized. IC(50) values for the following phytopathogens were determined: Aspergillus ochraceus AM 456, Fusarium culmorum AM 282, Fusarium oxysporum AM 13, Fusarium tricinctum AM 16. Effect of compound structures, especially stereogenic centers,(More)
Two racemic and two enantiomeric pairs of new saturated lactones with the p-menthane system were obtained. The lactones were synthesized from racemic and enantiomerically enriched cis- and trans-piperitols, which were obtained from piperitone. The structures of the compounds were confirmed by spectroscopic data. The antifeedant activity of piperitone to(More)
The metabolism of δ-iodo-γ-lactones containing cyclohexane ring with an increasing number of methyl substituents in Absidia cylindrospora was studied and seven metabolites were isolated as the products of biotransformations of these substrates. They were formed as the result of various dehalogenation pathways and four of them (hydroxylactones and(More)
In the structure of the title compound, C(18)H(16)O(4), both the S and R enanti-omers appear to occupy in a random way four symmetry-equivalent sites of the unit cell in an approximately 4:1/1:4 ratio. The chiral C atom of the pyrone ring together with the phenyl ring bonded to this atom are disordered over two positions, the occupancy factor of the major(More)
BACKGROUND In our previous studies bicyclic γ-lactones with cyclohexane ring exhibited high antifeedant activity against storage pests. The activity was correlated with the type and number of substituents in the cyclohexane ring. One of the most potent group of antifeedant agents was δ-iodo-γ-lactones. RESULTS We present the synthesis of new bicyclic(More)
In strychninium chlorate(VII) monohydrate, C21H23N2O2+.ClO4-.H2O, strychninium hydrogensulfate(VI) dihydrate, C21H23N2O2+.HSO4-.2H2O, and strychninium dihydrogenphosphate(V) dihydrate, C21H23N2O2+.H2PO4-.2H2O, the strychninium cations form bilayer sheets separated by water-anion sheets. The strychnine bilayer sheets in the three compounds are similar to one(More)