Afshin Fayyazi

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Testicular germ cell tumours (TGCT) represent the most common malignancies in young males. Whereas in 1970s, the survival rate in patients with metastatic testicular tumours was only 5%, these days, 80% of the patients treated by modern chemotherapy will survive their disease. The drug that revolutionised the cure rate for patients with metastatic(More)
OBJECTIVE Headache is a common disabling neurological disorder and migraine comprises more than half the causes of recurrent headaches in children. Despite extended prevalence of this type of headache there is lack of evidence about best drug treatment for migraine. So we aimed to compare the therapeutic effects of these drugs on childhood migraine. (More)
SNARE (soluble-N-ethylmaleimide-sensitive factor attachment receptor) proteins mediate the recognition and fusion of transport vesicles in eukaryotic cells. The SNARE protein VAMP8 (also called endobrevin) is involved in the fusion of late endosomes and in some pathways of regulated exocytosis. In a subset of mice deficient for the SNARE protein VAMP8, a(More)
OBJECTIVE The Pediatric Risk of Mortality (PRISM) score is one of the scores used by many pediatricians for prediction of the mortality risk in the pediatric intensive care unit (PICU). Herein, we intend to evaluate the efficacy of PRISM score in prediction of mortality rate in PICU. METHODS In this cohort study, 221 children admitted during an 18-month(More)
Cytokines possess discrepant effects on tumour cells varying from anti-to proapoptotic activities. We recently reported that testicular germ cell tumours (TGCT) express a functional form of the proinflammatory cytokine interferon-gamma (IFNg). The present study asked whether TGCT-derived IFNg influences survival or death of neoplastic germ cells. Analysis(More)
OBJECTIVE The effect of using omega-3 to prevent migraine attacks has been raised in recent studies. The majority of these studies have been conducted in adults. Conversely, other studies have yet to confirm the effect of omega-3. The main purpose of this study was to assess the effects of omega-3 in the prevention of migraine attacks in children. (More)
OBJECTIVE Bell's palsy is a rapid onset, usually, unilateral paralysis of the facial nerve that causes significant changes in an individual's life such as a decline in personal, social, and educational performance. This study compared efficacy of combined prednisolone and acyclovir therapy with prednisolone alone. MATERIALS & METHODS This study is a(More)
OBJECTIVE Many patients with late-diagnosed phenylketonuria (PKU) suffer from severe behavior problems. This study compares the effects of buspirone and risperidone on reducing behavior disorders in these patients. MATERIALS & METHODS In this crossover clinical trial study, patients with severe behavior disorders after medical examination were randomly(More)
Dear Editor Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral disorder in children (1). Prevailing theories suggest that this disease is caused by the disruption of dopamine transmission in the frontal lobe and frontostriatal pathway (2). The prevalence of such a disorder worldwide is approximately 5.2–12% (1)(2). ADHD is one of(More)
OBJECTIVE Febrile seizures (FSs) are the most common neurological disorder observed in the pediatric age group. The present study provides information about epidemiological and clinical characteristics as well as risk factors associated with FS among Iranian children. MATERIALS & METHODS On the computerized literature valid databases, the FS prevalence(More)