Afrodite Nonni

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BACKGROUND Hsp90 (heat shock protein90) is a chaperone protein essential for preserving and regulating the function of various cellular proteins. Elevated Hsp90 expression seems to be a trait of breast cancer and may be an integral part of the coping mechanisms that cancer cells exhibit vis-à-vis stress. This manuscript tries to examine the(More)
BACKGROUND Heat shock protein 90 (Hsp90) overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications. The purpose of this study is to evaluate the immunohistochemical expression of Hsp90 and to examine whether Hsp90 expression is associated with estrogen receptor alpha (ER-alpha) and beta (ER-beta)(More)
BACKGROUND Elevated Hsp90 expression has been documented in breast ductal carcinomas, whereas decreased Hsp90 expression has been reported in precursor lobular lesions. This study aims to assess Hsp90 expression in infiltrative lobular carcinomas of the breast. METHODS Tissue specimens were taken from 32 patients with infiltrative lobular carcinoma.(More)
A 40-year-old male presented to our outpatient department with the chief complaint of a painless mass on his right testis with gradual size increase over the past two months. Physical examination and ultrasound revealed a firm and nontender mass both on the right and on the left testis. The only elevated biomarker was b-hcG (24,7 mIU/mL) and computer(More)
Dear Editor, Core-needle biopsy with ultrasound guidance is a widely used and well-studied method for the differential diagnosis of non-palpable breast le-sions. However, the pain during the procedure is a rather neglected issue; in a recent issue of European Radiology , Hemmer et al. [1] provided an important insight into this topic, which affects a(More)
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