Aeju Lee

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Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.

Seulki Lee, Ju Hee Ryu, +11 authors Kwangmeyung Kim
Nano letters
2009

We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic… (More)

TNF-α gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis.

So Jin Lee, Aeju Lee, +10 authors Kwangmeyung Kim
Molecular therapy : the journal of the American…
2014

Among various proinflammatory cytokines involved in the pathogenesis of rheumatoid arthritis (RA), tumor necrosis factor (TNF)-α plays a pivotal role in the release of other cytokines and induction… (More)

Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe.

Ju Hee Ryu, Aeju Lee, +9 authors Inchan Youn
Arthritis and rheumatism
2011

OBJECTIVE Early treatment based on an early diagnosis of rheumatoid arthritis (RA) could halt progression of the disease, but early diagnosis is often difficult. Matrix metalloproteinase 3 (MMP-3) is… (More)

Real time, high resolution video imaging of apoptosis in single cells with a polymeric nanoprobe.

Seulki Lee, Ki Young Choi, +12 authors Kuiwon Choi
Bioconjugate chemistry
2011

We report a new apoptosis nanoprobe (Apo-NP) designed on the basis of a polymer nanoparticle platform. This simple one-step technique is capable of boosting fluorescence signals upon apoptosis in… (More)

Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy

J P Rhee, Ok kyu Park, Aeju Lee, Dae Hyeok Yang, Kyeongsoon Park
Marine drugs
2014

Theranostics is an integrated nanosystem that combines therapeutics with diagnostics in attempt to develop new personalized treatments with enhanced therapeutic efficacy and safety. As a promising… (More)

Detection of active matrix metalloproteinase-3 in serum and fibroblast-like synoviocytes of collagen-induced arthritis mice.

Aeju Lee, Sung-Jae Choi, +5 authors Inchan Youn
Bioconjugate chemistry
2013

The activity of rheumatoid arthritis (RA) correlates with the expression of proteases. Among several proteases, matrix metalloproteinase-3 (MMP-3) is one of the biological markers used to diagnose… (More)

"One-step" detection of matrix metalloproteinase activity using a fluorogenic peptide probe-immobilized diagnostic kit.

Ju Hee Ryu, Aeju Lee, +8 authors Kuiwon Choi
Bioconjugate chemistry
2010

Matrix metalloproteinases (MMPs) have been shown to be abundant in pathological conditions such as cancer, osteoarthritis (OA), and rheumatoid arthritis (RA). The extent of MMPs detected in… (More)

Measurement of MMP Activity in Synovial Fluid in Cases of Osteoarthritis and Acute Inflammatory Conditions of the Knee Joints Using a Fluorogenic Peptide Probe-Immobilized Diagnostic Kit

Ju Hee Ryu, Aeju Lee, +7 authors Inchan Youn
Theranostics
2012

PURPOSE A fluorogenic peptide probe-immobilized diagnostic kit was used to analyze MMP activity in the synovial fluids (SFs) from patients with osteoarthritis (OA) and acute inflammatory conditions… (More)

Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging

Ju Hee Ryu, Aeju Lee, +9 authors Kwangmeyung Kim
Amino Acids
2010

Among the classical collagenases, matrix metalloproteinase-13 (called MMP-13, collagenase-3) is one of the most important components for cartilage destruction of osteoarthritis (OA) developments.… (More)

Ameliorating Amyloid-β Fibrils Triggered Inflammation via Curcumin-Loaded Polymeric Nanoconstructs

Andrea Ameruoso, Roberto Palomba, +4 authors Paolo Decuzzi
Front. Immunol.
2017

Inflammation is a common hallmark in several diseases, including atherosclerosis, cancer, obesity, and neurodegeneration. In Alzheimer's disease (AD), growing evidence directly correlates neuronal… (More)

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