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WHAT IS KNOWN AND OBJECTIVE Genetic polymorphisms of thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA 94C>A) contribute to variable responses, including fatal adverse effects, among subjects treated with 6-mercaptopurine (6-MP). Our objectives were to investigate the distribution of specific TPMT and ITPA genotypes(More)
AIM The aim of this study was to highlight various anomalies associated with undescended testis and to determine how much work up is necessary for this condition. MATERIAL AND METHODS The study was conducted in the department of Pediatric Surgery SKIMS Srinagar, Kashmir. All patients between 0-14 years of age who attended out patient department (OPD) from(More)
BACKGROUND AND PURPOSE There is no general consensus as to whether autoimmune myasthenia gravis (MG) is associated with heart diseases, despite the fact that myocarditis, a serious cardiac involvement treatable by immunotherapy, is a complication of MG. It has been observed previously that MG patients with clinically suspected myocarditis had anti-Kv1.4(More)
WHAT IS KNOWN AND OBJECTIVE The introduction and success of imatinib mesylate (IM) has brought about a paradigm shift in chronic myeloid leukaemia (CML) treatment. However, despite the high efficacy of IM, clinical resistance develops due to a heterogeneous array of mechanisms. Pharmacogenetic variability as a result of genetic polymorphisms could be one of(More)
BACKGROUND Ascariasis is the commonest intestinal nematodal infestation in man. Ascariasis commonly inhabits small bowel although it can migrate to biliary tree and other orifices. The aim of this study is to analyze the presentation, diagnosis, management of bowel obstruction caused by Ascaris lumbricoides and to study various surgical complications. (More)
BACKGROUND Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible. METHODS Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and 10 healthy volunteers were analysed using(More)
Prune belly syndrome (PBS) is a rare congenital constellation of defects in pediatric surgical practice. Although anorectal anomalies have been reported in association with PBS, only few case of pouch colon with PBS has been reported. [1] In addition, our patient had deficient abdominal wall with absent dermatome in left upper quadrant, which has never been(More)
BACKGROUND One quarter of the world's population is known to be infected with ascariasis. It is endemic in various parts of the Indian subcontinent with a high incidence in the Kashmir valley. Although intestinal obstruction is the commonest complication of ascariasis in children, biliary ascariasis remains the second most common complication. We aimed to(More)
Pelvic genital hydatid disease is rare. It accounts for only 0.9% of hydatidoses and 1.8% of operated adnexial masses. Its clinical signs are often misleading, making the preoperative diagnosis difficult. This diagnosis rests on questioning with particular attention to the socio-professional context and previous history of hydatid disease. Ultrasonography(More)