Lon protease is a multifunction protein and operates in protein quality control and stress response pathways in mitochondria. Human Lon is upregulated under oxidative and hypoxic stresses that represent the stress phenotypes of cancer. However, little literature undertakes comprehensive and detailed investigations on the tumorigenic role of Lon.… (More)
This study presents a theoretically motivated analysis of learning and performance on a micro-processor based oscilloscope. An analysis of the knowledge required to make basic measurements was done using the GOMS model and Cognitive Complexity Theory (CCT). From these analyses and the criterion used in Polson, Muncher, and Engelbeck (1986), tasks were… (More)
Human Lon protease is a mitochondrial matrix protein with several functions, including protein degradation, mitochondrial DNA (mtDNA) binding, and chaperone activity. Lon is currently emerging as an important regulator of mitochondria-contributed tumorigenesis due to its overexpression in cancer cells. To understand the mechanism of increased Lon in tumor… (More)
Prophylaxis is considered optimal care for hemophilia patients to prevent bleeding and to preserve joint function thereby improving quality of life (QoL). The evidence for prophylaxis is irrefutable and is the standard of care in developed nations. Prophylaxis can be further individualized to improve outcomes and cost effectiveness. Individualization is… (More)
Testing expert and novice detection behaviors with eye tracking and Pathfinder networks. Unpublished Doctoral dissertation, New Mexico State University.