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Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis.
- Romana Meletta, R. Slavik, +6 authors Adrienne Müller Herde
- Biology, Medicine
- Nuclear medicine and biology
- 1 April 2017
INTRODUCTION
Endarterectomized human atherosclerotic plaques are a valuable basis for gene expression studies to disclose novel imaging biomarkers and therapeutic targets, such as the cannabinoid… Expand
Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions.
- A. Chiotellis, Filippo Sladojevich, +6 authors Thomas L. Mindt
- Chemistry, Medicine
- Chemical communications
- 26 April 2016
We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous… Expand
Synthesis, Radiolabeling, and Biological Evaluation of 5-Hydroxy-2-[(18)F]fluoroalkyl-tryptophan Analogues as Potential PET Radiotracers for Tumor Imaging.
- A. Chiotellis, Adrienne Müller Herde, +7 authors S. Ametamey
- Chemistry, Medicine
- Journal of medicinal chemistry
- 26 May 2016
Aiming at developing mechanism-based amino acid (18)F-PET tracers for tumor imaging, we synthesized two (18)F-labeled analogues of 5-hydroxy-l-[β-(11)C]tryptophan ([(11)C]5HTP) whose excellent in… Expand
Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis
- Romana Meletta, Adrienne Müller Herde, P. Dennler, E. Fischer, R. Schibli, S. Krämer
- Medicine
- EJNMMI Research
- 4 January 2016
BackgroundThe inflammatory nature of atherosclerosis provides a broad range of potential molecular targets for atherosclerosis imaging. Growing interest is focused on targets related to plaque… Expand
Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.
- R. Slavik, U. Grether, +7 authors S. Ametamey
- Chemistry, Medicine
- Journal of medicinal chemistry
- 14 May 2015
As part of our efforts to develop CB2 PET imaging agents, we investigated 2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands. A total of 21 novel compounds were designed,… Expand
Discovery of a fluorinated 4‐oxo‐quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2
- R. Slavik, Adrienne Müller Herde, +5 authors L. Mu
- Chemistry, Medicine
- Journal of neurochemistry
- 1 July 2016
The cannabinoid receptor type 2 (CB2) is part of the endocannabinoid system and has gained growing attention in recent years because of its important role in neuroinflammatory/neurodegenerative… Expand
Evaluation of the Radiolabeled Boronic Acid-Based FAP Inhibitor MIP-1232 for Atherosclerotic Plaque Imaging
- Romana Meletta, Adrienne Müller Herde, +6 authors R. Schibli
- Chemistry, Medicine
- Molecules
- 27 January 2015
Research towards the non-invasive imaging of atherosclerotic plaques is of high clinical priority as early recognition of vulnerable plaques may reduce the incidence of cardiovascular events. The… Expand
Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging
- A. Haider, Adrienne Müller Herde, +6 authors Simon Mensah Ametamey
- Chemistry, Medicine
- Front. Neurosci.
- 27 July 2016
Over the past two decades, our understanding of the endocannabinoid system has greatly improved due to the wealth of results obtained from exploratory studies. Currently, two cannabinoid receptor… Expand
Quantitative positron emission tomography of mGluR5 in rat brain with [18F]PSS232 at minimal invasiveness and reduced model complexity
- Adrienne Müller Herde, C. Keller, +4 authors S. Krämer
- Biology, Medicine
- Journal of neurochemistry
- 1 May 2015
Imaging the density of metabotropic glutamate receptor 5 (mGluR5) in brain by positron emission tomography (PET) is of interest in relation to several brain disorders. We have recently introduced… Expand
Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats
- Adrienne Müller Herde, Yoan Mihov, +4 authors G. Hasler
- Medicine
- Neurotoxicity Research
- 22 May 2019
Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect… Expand