Skip to search formSkip to main contentSkip to account menu

Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis.

View on PubMed (opens in a new tab)

Preclinical imaging of the co-stimulatory molecules CD80 and CD86 with indium-111-labeled belatacept in atherosclerosis

TLDR
DOTA-belatacept accumulates in CD80/CD86-positive tissues in vivo and in vitro rendering it a research tool for the assessment of inflammatory activity in atherosclerosis and possibly other diseases.
View on Springer (opens in a new tab)

Evaluation of the Radiolabeled Boronic Acid-Based FAP Inhibitor MIP-1232 for Atherosclerotic Plaque Imaging

TLDR
Target expression analyses revealed a moderately higher protein level in atherosclerotic plaques than normal arteries correlating with plaque vulnerability, and binding of the tracer to endarterectomized tissue was similar in plaques and normal arteries, hampering its use for atherosclerosis imaging.
View PDF (opens in a new tab)

Quantitative positron emission tomography of mGluR5 in rat brain with [18F]PSS232 at minimal invasiveness and reduced model complexity

TLDR
This work aimed at minimizing invasiveness of IF recording in rat and employing this protocol for mGluR5 quantitative PET with [18F]PSS232, an F‐18‐labeled analog of the mGLUR5‐targeting [11C]ABP688, and defining models of low complexity for quantitativePET with [ 18F] PSS232.
View on Wiley (opens in a new tab)

Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats

TLDR
It is demonstrated that chronic nicotine administration alters behaviour and mGluR5 availability and Chronic nicotine administration leads to decreased [18F]PSS232 binding which normalizes after prolonged nicotine withdrawal.
View on Springer (opens in a new tab)

Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging.

TLDR
PET experiments suggested that [18F]15 and [11C]2 are of limited utility for the PET imaging of brain 5-HT3 receptors in vivo, while in vitro autoradiography with both compounds revealed a heterogeneous and displaceable binding in cortical and hippocampal regions that are known to express 5- HT3 receptors at significant levels.
View on PubMed (opens in a new tab)

Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.

TLDR
2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands investigated for their potency and binding properties toward human and rodent CB1 and CB2 and 16 is a promising radiotracer for imaging CB2 in rodents.
View on PubMed (opens in a new tab)

Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging

TLDR
The obtained results revealed unspecific binding in spleen tissue that was not blocked by an excess of CB2-specific ligand GW402833, and a suitable positron emission tomography tracer to visualize the CB2 receptor in patients suffering from neurodegenerative diseases is developed.
View on PubMed (opens in a new tab)

Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions.

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous…
View on PubMed (opens in a new tab)

Discovery of a fluorinated 4‐oxo‐quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

TLDR
Three novel fluorinated analogs of RS‐126 demonstrated high specificity toward CB2 receptor in vitro and in vivo and is a promising radioligand for imagingCB2 receptor expression.
View on Wiley (opens in a new tab)
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)