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Based on the discrete definition of biological regulatory networks developed by René Thomas, we provide a computer science formal approach to treat temporal properties of biological regulatory networks, expressed in computational tree logic. It is then possible to build all the models satisfying a set of given temporal properties. Our approach is… (More)

The biologist René Thomas conjectured, twenty years ago, that the presence of a negative feedback circuit in the interaction graph of a dynamical system is a necessary condition for this system to produce sustained oscillations. In this paper, we state and prove this conjecture for asynchronous automata networks, a class of discrete dynamical systems… (More)

Given a Boolean function F : {0, 1} n → {0, 1} n , and a point x in {0, 1} n , we represent the discrete Jacobian matrix of F at point x by a signed directed graph G F (x). We then focus on the following open problem: Is the absence of a negative circuit in G F (x) for every x in {0, 1} n a sufficient condition for F to have at least one fixed point? As… (More)

Boolean networks are discrete dynamical systems extensively used to model biological regulatory networks. The dynamical analysis of these networks suffers from the combinatorial explosion of the state space, which grows exponentially with the number n of components. To face this problem, a classical approach consists in deducing from the interaction graph… (More)

R. Thomas conjectured, twenty years ago, that the presence of a positive circuit in the interaction graph of a dynamical system is a necessary condition for the presence of several stable states. Recently, E. Remy et al. stated and proved the conjecture for Boolean dynamical systems. Using a similar approach, we generalize the result to discrete dynamical… (More)

We consider a product X of n finite intervals of integers, a map F from X to itself, the asynchronous state transition graph Γ(F) on X that Thomas proposed as a model for the dynamics of a network of n genes, and the interaction graph G(F) that describes the topology of the system in terms of positive and negative interactions between its n components.… (More)

In the field of biological regulation, models extracted from experimental works are usually complex networks comprising intertwined feedback circuits. The overall behavior is difficult to grasp and the development of formal methods is needed in order to model and simulate biological regulatory networks. To model the behavior of such systems, R. Thomas and… (More)

In this paper, we are interested in the number of fixed points of functions f : A n → A n over a finite alphabet A defined on a given signed digraph D. We first use techniques from network coding to derive some lower bounds on the number of fixed points that only depends on D. We then discover relationships between the number of fixed points of f and… (More)

In this paper, we propose a refinement of the modelling of biological regulatory networks based on the discrete approach of Rene Thomas. We refine and automatise the use of delays of activation/inhibition in order to specify which variable is more quickly affected by a change of its regulators. The formalism of linear hybrid automata is well suited to allow… (More)

It has been proved, for several classes of continuous and discrete dynamical systems, that the presence of a positive (resp. negative) circuit in the interaction graph of a system is a necessary condition for the presence of multiple stable states (resp. a cyclic attractor). A positive (resp. negative) circuit is said to be functional when it "generates"… (More)