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Biliverdin IXbeta reductase (BVR-B) catalyzes the pyridine nucleotide-dependent production of bilirubin-IXbeta, the major heme catabolite during early fetal development. BVR-B displays a preference for biliverdin isomers without propionates straddling the C10 position, in contrast to biliverdin IXalpha reductase (BVR-A), the major form of BVR in adult human(More)
The three-dimensional crystal structure of pi class glutathione S-transferase YfYf from mouse liver complexed with the inhibitor S-(p-nitrobenzyl)glutathione has been determined at 1.8 A resolution by X-ray diffraction. In addition two complexes with glutathione sulphonic acid and S-hexylglutathione have been determined at resolutions of 1.9 and 2.2 A,(More)
Intensity Modulated Radiotherapy is a new technique enabling the sculpting of the 3D radiation dose. It enables to modulate the delivery of the dose inside the malignant areas and constrain the radiation plan for protecting important functional areas. It also raises the issues of adequacy and accuracy of the selection and delineation of the target volumes.(More)
In this paper we compare three non-rigid registration methods for atlas-based segmentation: B-splines, morphons and a combination of morphons and demons. To assess the quality of each method, we use a data set of four patients, containing for each patient the computed tomography (CT) image and a manual segmentation of the organs at risk performed by an(More)
In this paper we present a methodology to build a computational anatomical atlas based on the analysis of dense deformation fields recovered by the Morphons non-rigid registration algorithm. The anatomical atlas construction procedure is based on the minimization of the effort required to register the whole database to a reference. The suitability of our(More)
BACKGROUND AND PURPOSE Weight loss, tumor shrinkage, and tissue edema induce substantial modification of patient's anatomy during head and neck (HN) radiotherapy (RT) or chemo-radiotherapy. These modifications may impact on the dose distribution to both target volumes (TVs) and organs at risk (OARs). Adaptive radiotherapy (ART) where patients are re-imaged(More)
The internal symmetry of the connector or portal particle from the double-stranded DNA bacteriophage phi29 has been examined by X-ray crystallography. This large multimeric structure (420 kDa) is built up by a number of identical subunits of the p10 protein. It connects the head of the virus with the tail and plays a central role in the prohead assembly and(More)
The structure of the 45 amino acid transcriptional repressor, CopG, has been solved unliganded and bound to its target operator DNA. The protein, encoded by the promiscuous streptococcal plasmid pMV158, is involved in the control of plasmid copy number. The structure of this protein repressor, which is the shortest reported to date and the first isolated(More)
The signal transduction protein CheY displays an alpha/beta-parallel polypeptide folding, including a highly unstable helix alpha4 and a strongly charged active site. Helix alpha4 has been shown to adopt various positions and conformations in different crystal structures, suggesting that it is a mobile segment. Furthermore, the instability of this helix is(More)