Adriane Morris

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unease about a potential link between vaccination with the triple vaccine MMR (mumps, measles, and rubella) and autism or bowel inflammatory conditions, with some hundreds of parents of afflicted children undertaking legal action against the manufacturers. There is no space to go into detail of the controversy over the link here (search the web using(More)
The intrinsic fluorescence properties of human alpha apohemoglobin at protein concentrations from 1 to 5 microM in 0.1 M potassium phosphate buffer, pH 7 or 8 at 5 degrees C were monitored in the absence and presence of a fixed concentration (5 microM) of a fluorescence quenching heme-containing native or Des (146-His, 145-Tyr) beta chain partner. These(More)
The down-regulation of major histocompatibility complex (MHC) antigen expression which occurs in tumours may be an important element in tumour progression - the increasing malignancy of tumours - which is so much a feature of cancer - if it allowed the avoidance of T-cell immunity. Obviously, this downregulation could be due to a wide variety of mechanisms.(More)
A broad beta chain band region containing multiple components was observed with both native beta and Des(His-146, Tyr-145) beta chains following isoelectric focusing on agarose gels (pH 6.0-8.0). In contrast to the tetramer-monomer system of beta chains, a distinct separation of three components (tetramer, dimer and monomer) was seen for Des(His-146,(More)
The interaction of heme-free alpha (alpha(o)) and heme-containing beta (beta(h)) chains of human hemoglobin has been monitored in 0.1 M potassium phosphate buffer, pH 7 or 8, at 5 degrees C. Soret zero and first-derivative spectra were consistent with a uniform association reaction. Stopped-flow investigations demonstrated association rates on the order of(More)
The rates of alpha/beta monomer combination of four beta(A) variants (beta 112C --> S, beta 112C --> D, beta 112C --> T, and beta 112C --> V) in the presence and absence of beta 16G --> D (beta(J)) were measured in an attempt to assess the consequences of amino acid substitution at both a surface (beta 16) and an alpha(1)beta(1) interface (beta 112) residue(More)
The subunit assembly properties of isolated beta and Des(His-146,Tyr-145) beta chains of sickle hemoglobin were investigated by isoelectric focusing over a protein concentration range from 500-125 microM in heme. Two components (presumably tetramer and monomer) and three components (designated tetramer, dimer and monomer) were visualized for beta s and(More)