Adriana de Fátima Vasconcelos Pereira

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Poly(ε-caprolactone) implants containing etoposide, an important chemotherapeutic agent and topoisomerase II inhibitor, were fabricated by a melt method and characterized in terms of content uniformity, morphology, drug physical state, and sterility. In vitro and in vivo drug release from the implants was also evaluated. The cytotoxic activity of implants(More)
Salivary IgA can serve as a first line of defense against pathogens that colonize and invade mucosal surfaces and may be protective against periodontal disease. The aim of this study was to assess salivary immunoglobulin A levels in diabetic and non-diabetic patients with different periodontal treatment needs. The Periodontal Screening & Recording (PSR)(More)
This study reports the development and validation of an analytical UV spectrophotometric methodfor determination of methotrexate incorporated into implants based on poly(ε-caprolactone) and released from them. The detection of the drug was carried out in 0.1 ml/L hydrochloric acid at 307 nm. It provided specificity for the methotrexate in direct contact(More)
The aim of this study was to observe the influence of restorative techniques on marginal adaptation and dye penetration around Class V restorations simulating abfraction lesions. Sixty mandibular premolars were divided into six groups (n = 10) using different restorative materials. Cavity preparation presented the gingival wall localized in dentin and the(More)
An HPLC method was developed and validated aiming to quantify the triamcinolone acetonide incorporated into intraocular implants based on polyurethaneand in direct contact with the degradation products of this biomaterial. The separation was carried out in less than 5 minutes using acetonitrile/water (50:50) as mobile phase, a C18 column and ultraviolet(More)
OBJECTIVE to describe characteristics of oral health care during prenatal check-ups and knowledge about oral health among pregnant women using public and private health services in São Luís, Maranhão, Brazil. METHODS this is a descriptive study of 300 women interviewed in public health services and a further 300 interviewed in private health services(More)
OBJECTIVE To evaluate the effect of 3% phosphate ascorbyl gel (PA) in different times onto the microshear bond strength of composite resin (CR) to bovine enamel treated with 35% hydrogen peroxide (HP). MATERIALS AND METHODS Thirty enamel blocks of bovine incisors were made and divided into 5 groups (n = 6) with three specimens per group (n = 18),(More)
PURPOSE to verify the association of osteoporosis with periodontal disease. METHODS the study has included 39 postmenopausal women divided in three groups according to bone mass categories, through evaluation of mineral bone density (MBD), measured by X-ray double emission absorbimetry in the lumbar area (L1-L4): ): normal bone; osteopenia and(More)
OBJECTIVE To assess the systemic bone mineral density (BMD) and the periodontal situation in postmenopausal women, to understand the possible role of osteoporosis as a risk factor for periodontal disease. METHODS The sample was comprised of 47 postmenopausal women, divided into 3 groups: 14 patients with normal bones (G1), 17 with osteopenia (G2) and 16(More)
CONTEXT Methotrexate (MTX) is used in the treatment of malignancies; however, its clinical application is limited by its toxic dose-related side effects. An alternative to overcome the toxicity of the MTX in healthy tissues is the design of an implantable device capable of controlling the delivery of this drug for an extended period within the tumor site.(More)
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