Adriana Martín

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OBJECTIVE The objective of this study is to evaluate the economic benefits of immunoglobulin replacement therapy achieved subcutaneously (subcutaneous immunoglobulin, SCIG) by the rapid push method compared to intravenous infusion therapy (intravenous immunoglobulin, IVIG) in primary immune deficiency (PID) patients from the healthcare system perspective in(More)
The development of accessible Web software is complicated for several reasons. Though some of them are technological, the majority are related with the need to compose different and, many times, unrelated design concerns which may be functional as in the case of most of the specific application’s requirements, or non-functional such as Accessibility itself.(More)
Usually, a huge number of tools and proposals help developers assess Accessibility of Web applications; however, looking from the designer perspective, there is no such a similar situation. It seems that creating accessible Web sites is more expensive and complicated than creating Web sites and then assessing/modifying them. Although this feeling may be(More)
Although Accessibility has not yet gained much recognition as a crucial non-functional requirement like security, performance, accuracy and usability, it is a vital attribute for people with disabilities. Developing accessible Web applications is usually hard for several reasons. Firstly, there is a significant knowledge gap between developers and(More)
The lack of adequate Accessibility of Web sites remains a problem for blind users and other people with disabilities. The process of engineering accessible Web applications involves several issues, which include content, presentation and pragmatic issues that, fortunately, are currently addressed by some standard models such as the W3C's Accessibility(More)
Currently, Web-based applications without personalization and developed with "ad hoc" practices are requiring substantial evolution. Particularly, e-commerce applications are implicitly bound to a fully customisable fashion, attending individual users or group of users needs. Hence, personalization is a leader performance feature of today's Web applications(More)
The design and synthesis of enhanced membrane-intercalating biomaterials for drug delivery or vascular membrane targeting is currently challenged by the lack of screening and prediction tools. The present work demonstrates the generation of a Quantitative Structural Activity Relationship model (QSAR) to make a priori predictions. Amphiphilic macromolecules(More)
BACKGROUND Hypertension is associated with increased cardiovascular deaths in patients with acromegaly. OBJECTIVE To evaluate the accuracy of blood pressure (BP) by 24-h ambulatory blood pressure monitoring (ABPM) and office BP measurements to represent the real BP status in acromegalic patients and its relationship with acromegalic activity and(More)
Methods A cohort study of 57 PID patients was reviewed 3 months post-transition to the 20% Subcutaneous Immunoglobulin (HizentraTM), in order to evaluate clinical outcomes and adverse events related to a dose-equivalent switch from 10% liquid solution intravenous (Privigen and Gamunex) or 16% subcutaneous replacement therapy (Vivaglobin) to weekly infusion(More)
Background Immunoglobulin replacement therapy is standard of care for patients with primary humoral immunodeficiency [1]. Compared with intravenous immunoglobulin (IVIG), subcutaneous immunoglobulin (SCIG) offers comparable efficacy, lower costs and reduced systemic reactions [2,3]. However, little is known about effects on quality of life when patients(More)