Adriana Climescu-Haulica

Learn More
Most of the data analysis of microarray gene expression data use a clustering algorithm, as a preprocessing step, in genomic functional analysis for example [6] or as the main discriminating tool, in the tumor classification study [9]. While from the experimenter point of view the simplest clustering method could be the best, it is acknowledged [8] that the(More)
This work explores the quantitative characteristics of the local transcriptional regulatory network based on the availability of time dependent gene expression data sets. The dynamics of the gene expression level are fitted via a stochastic differential equation model, yielding a set of specific regulators and their contribution. We show that a beta sigmoid(More)
Protocadherins are transmembrane proteins exhibiting homophilic adhesive activities through their extracellular domain. Protocadherin 12 (Pcdh12) is expressed in angiogenic endothelial cells, mesangial cells of kidney glomeruli, and glycogen cells of the mouse placenta. To get insight into the role of this protein in vivo, we analyzed PCDH12-deficient mice(More)
In the context of stochastic dependency of the noise and signal - as in the case of the reverberation noise - the classical methods of signal detection are not applicable. The paper presents a likelihood ratio detection method based on stochastic calculus. The novel aspects of the method are: the signal and the noise need not be stochastically independent(More)
Protocadherins are transmembrane proteins exhibiting homophilic adhesive activities through their extracellular domain. Pcdh12 is expressed in angiogenic endothelial cells, mesangial cells of kidney glomeruli and glycogen cells of the mouse placenta. To get insights into the role of this protein in vivo, we analyzed PCDH12-deficient mice and investigated(More)
Computational Biology Center, IBM T.J. Watson Research Center, Yorktown Hts. NY 10598 USA Email:[galexe,gyan]@us.ibm.com The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA Department of Biomedical Engineering, Boston University, Boston MA 02215, USA 4 Laboratoire Modélisation et Calcul, IMAG 38041 Grenoble, France(More)
  • 1