Adriana C. Gittenberger-de Groot

Marco C. DeRuiter4
Lambertus J. Wisse3
Michelle Olive2
4Marco C. DeRuiter
3Lambertus J. Wisse
2Michelle Olive
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Endothelial progenitor cells (EPC) play a central role in endothelial maintenance and repair. Endothelial colony-forming cells (ECFC) form a subpopulation of EPC. ECFC are readily attainable, can be easily isolated, possess a high proliferation potential, and are therefore a promising source of endothelial cells (EC) for future cardiovascular therapeutic(More)
It is evident that hemodynamic factors have a dominant function already during early cardiogenesis. Flow and ensuing shear stress are sensed by endothelial cells by, ciliary modified, cytoskeletal deformation which then activates a number of subcellular structures and molecules. Shear stress dependent changes mostly converge towards NF kappa B signaling and(More)
Closure of the ductus arteriosus (DA) at birth is essential for the transition from fetal to postnatal life. Before birth the DA bypasses the uninflated lungs by shunting blood from the pulmonary trunk into the systemic circulation. The molecular mechanism underlying DA closure and degeneration has not been fully elucidated, but is associated with apoptosis(More)
During cardiogenesis the epicardium, covering the surface of the myocardial tube, has been ascribed several functions essential for normal heart development of vertebrates from lampreys to mammals. We investigated a novel function of the epicardium in ventricular development in species with partial and complete septation. These species include reptiles,(More)
BACKGROUND Heart development is a complex process, and abnormal development may result in congenital heart disease (CHD). Currently, studies on animal models mainly focus on cardiac morphology and the availability of hemodynamic data, especially of the right heart half, is limited. Here we aimed to assess the morphological and hemodynamic parameters of(More)
  • Noortje A. M. Bax, Angelique A. M. van Oorschot, Saskia Maas, Jerry Braun, John van Tuyn, Antoine A. F. de Vries +2 others
  • 2011
Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibroblasts, which contribute to cardiac(More)
Lipoprotein-related receptor protein 2 (LRP2) is important for development of the embryonic neural crest and brain in both mice and humans. Although a role in cardiovascular development can be expected, the hearts ofLrp2knockout (KO) mice have not yet been investigated. We studied the cardiovascular development ofLrp2KO mice between embryonic day 10.5(More)
  • Rebecca Vicente-Steijn, Roderick W. C. Scherptong, Boudewijn P. T. Kruithof, Sjoerd N. Duim, Marie Jose T. H. Goumans, Lambertus J. Wisse +8 others
  • 2015
BACKGROUND Morphological and functional differences of the right and left ventricle are apparent in the adult human heart. A differential contribution of cardiac fibroblasts and smooth muscle cells (populations of epicardium-derived cells) to each ventricle may account for part of the morphological-functional disparity. Here we studied the relation between(More)
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