Adrian W.R. Serohijos

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Understanding the relative contributions of various evolutionary processes-purifying selection, neutral drift, and adaptation-is fundamental to evolutionary biology. A common metric to distinguish these processes is the ratio of nonsynonymous to synonymous substitutions (i.e., dN/dS) interpreted from the neutral theory as a null model. However, from(More)
The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to infer the fitness effects of mutations and their dynamics of fixation. However, the role and contribution of molecular biophysics to these observations remain unclear. Here, we couple robust findings(More)
The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to infer the fitness effects of mutations and their dynamics of fixation. However, the role and contribution of molecular biophysics to these observations remain unclear. Here, we couple robust findings(More)
The ligase Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrates. Substrate recognition and binding are critical for the regulation of this reaction. Like closely related ligases, Itch can interact with proteins containing a PPXY motif via its WW domains. In addition to these WW domains, Itch(More)
Inferring the selection window in antimicrobial resistance using deep mutational 1 scanning data and biophysics-based fitness models 2 3 4 Pouria Dasmeh, Anh-Tien Ton, Caroline Quach, Adrian W.R. Serohijos 5 6 Departement de Biochimie, Centre Robert Cedergren en Bioinformatique et Génomique, Université de 7 Montréal, 2900 Edouard-Montpetit, Montreal, Quebec(More)
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