Adrian Vella

Sort by:

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

John A. Todd, Neil M. Walker, +37 authors David G. Clayton
Nature Genetics
2007

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows… (More)

Roux-en-Y gastric bypass vs intensive medical management for the control of type 2 diabetes, hypertension, and hyperlipidemia: the Diabetes Surgery Study randomized clinical trial.

Sayeed Ikramuddin, Judith Korner, +16 authors John P. Bantle
JAMA
2013

IMPORTANCE Controlling glycemia, blood pressure, and cholesterol is important for patients with diabetes. How best to achieve this goal is unknown. OBJECTIVE To compare Roux-en-Y gastric bypass… (More)

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.

Deborah J. Smyth, Jason. D Cooper, +20 authors John A. Todd
Diabetes
2004

In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and association results have been rare to date. Recently, it has been reported… (More)

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.

Adrian Vella, Jason. D Cooper, +12 authors John A. Todd
American journal of human genetics
2005

As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha)… (More)

Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity.

Ananda Basu, Rita Basu, +6 authors Robert A. Rizza
Diabetes
2000

Insulin-induced stimulation of muscle glucose uptake (MGU) is impaired in people with type 2 diabetes. To determine whether insulin-induced stimulation of splanchnic glucose uptake (SGU) is also… (More)

Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity.

Ananda Basu, Rita Basu, +6 authors Robert A. Rizza
Diabetes
2001

We have previously reported that splanchnic glucose uptake, hepatic glycogen synthesis, and hepatic glucokinase activity are decreased in people with type 2 diabetes during intravenous glucose… (More)

Common Genetic Variation in GLP1R and Insulin Secretion in Response to Exogenous GLP-1 in Nondiabetic Subjects

Airani Sathananthan, Chiara Dalla Man, +8 authors Adrian Vella
Diabetes care
2010

OBJECTIVE Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. The effect of genetic variation at this locus on the response to GLP-1 is unknown. This study assessed the effect of GLP1R… (More)

Secular Trends in the Presentation and Management of Functioning Insulinoma at the Mayo Clinic, 1987–2007

Kimberly A. Placzkowski, Adrian Vella, +6 authors F. John Service
The Journal of clinical endocrinology and…
2009

OBJECTIVE The objective of the study was to assess changes in the presentation and diagnostic and radiological evaluation of patients with surgically confirmed insulinoma at the Mayo Clinic… (More)

Roux-en-Y gastric bypass for diabetes (the Diabetes Surgery Study): 2-year outcomes of a 5-year, randomised, controlled trial.

Sayeed Ikramuddin, Charles J. Billington, +19 authors Judith Korner
The lancet. Diabetes & endocrinology
2015

BACKGROUND Conventional treatments for patients with type 2 diabetes are often inadequate. We aimed to assess outcomes of diabetes control and treatment risks 2 years after adding Roux-en-Y gastric… (More)

The Oral Minimal Model Method

Claudio Cobelli, Chiara Dalla Man, Gianna Maria Toffolo, Rita Basu, Adrian Vella, Robert A. Rizza
Diabetes
2014

The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We review the oral minimal… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences