Adrian Thorogood

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BACKGROUND Aerobic exercise is a common nonpharmacological intervention for the management of obesity. However, the efficacy of isolated aerobic exercise at promoting weight loss is unclear. We conducted a systematic review and meta-analysis to evaluate the efficacy of isolated aerobic exercise programs in overweight and obese populations. METHODS We(More)
volume 31 NumBeR 5 mAY 2013 nature biotechnology researchers and yet not to discourage access. We have surveyed available literature, policies and access agreements in an attempt to identify access norms, which have been captured by the GAA. Its utility, however, extends beyond suggesting best practices, as it also aims to enhance international(More)
We propose a standard model for a novel data access tier – registered access – to facilitate access to data that cannot be published in open access archives owing to ethical and legal risk. Based on an analysis of applicable research ethics and other legal and administrative frameworks, we discuss the general characteristics of this Registered Access Model,(More)
looking back over the policy statements of the Human Genome Organisation’s (HUGO) Ethics Committee (EC) and of its Intellectual Property Committee (IPC) is more than just a trip down memory lane; it is the revelation of a seismic shift in the values underlying genomic research (Table 1). Founded in 1992 at the inception of the Human Genome Project, HUGO not(More)
High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell receptor repertoires has increased dramatically since the technique was introduced in 2009 (1-3). This experimental approach explores the maturation of the adaptive immune system and its response to antigens, pathogens, and disease conditions in exquisite detail. It(More)
A deluge of genetic and health-related data is being generated about patients with dementia. International sharing of these data accelerates dementia research. Seeking consent to data sharing is a challenge for dementia research where patients have lost or risk losing legal capacity. The laws of most countries enable substitute decision makers (SDMs) to(More)
Three hundred consecutive requests for a domiciliary visit for pain relief were reviewed to assess the type of case referred by general practitioners and what treatment was instituted. Two hundred and thirty one (77%) were requested for lumbago/sciatica. In total 179 caudal epidurals and 49 other injections were performed in the patient's home. The safety(More)
BACKGROUND This article outlines procedures for the feedback of individual research data to participants. This feedback framework was developed in the context of a personalized medicine research project in Canada. Researchers in this domain have an ethical obligation to return individual research results and/or material incidental findings that are(More)
Public variant databases support the curation, clinical interpretation, and sharing of genomic data, thus reducing harmful errors or delays in diagnosis. As variant databases are increasingly relied on in the clinical context, there is concern that negligent variant interpretation will harm patients and attract liability. This article explores the evolving(More)