Adrian L. Harris

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Guidelines for the use and interpretation of assays for monitoring autophagy.

Daniel J Klionsky, Fábio Camargo Abdalla, +497 authors Motoni Kadowaki
Autophagy
2012

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… (More)

Hypoxia — a key regulatory factor in tumour growth

Adrian L. Harris
Nature Reviews Cancer
2002

Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death. Cancer cells have… (More)

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Charles C. Wykoff, Nigel J. P. Beasley, +10 authors Adrian L. Harris
Cancer research
2000

The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns in tumors, although the range of responding genes is still incompletely… (More)

Breast cancer classification and prognosis based on gene expression profiles from a population-based study.

Christos Sotiriou, Soek-Ying Neo, +7 authors Edison T. Liu
Proceedings of the National Academy of Sciences…
2003

Comprehensive gene expression patterns generated from cDNA microarrays were correlated with detailed clinico-pathological characteristics and clinical outcome in an unselected group of 99… (More)

Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade.

Sherene Loi, Benjamin Haibe-Kains, +14 authors Christos Sotiriou
Journal of clinical oncology : official journal…
2007

PURPOSE A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associated… (More)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raju R. Raval, Kah Weng Lau, +7 authors Peter J Ratcliffe
Molecular and cellular biology
2005

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (HIF-1alpha and HIF-2alpha), leading to constitutive… (More)

Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas.

Jacqueline S. Lewis, Robert J Landers, James C E Underwood, Adrian L. Harris, Claire E. Lewis
The Journal of pathology
2000

Angiogenesis is essential to the growth and metastasis of solid tumours. Vascular endothelial growth factor (VEGF) is a potent pro-angiogenic cytokine that is overexpressed in malignant tumours such… (More)

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Rebecca J. Appelhoff, Y A Tian, +5 authors Jonathan Gleadle
The Journal of biological chemistry
2004

Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis. The heterodimeric HIF complex is regulated by proteolysis of its… (More)

Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation.

Peter B. Vermeulen, Giampietro Gasparini, +8 authors Luc Y Dirix
European journal of cancer
1996

microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer.

Francesca Buffa, Carme Camps, +6 authors Jiannis Ragoussis
Cancer research
2011

microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated the benefits of a joint microRNA-mRNA… (More)

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