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Data Set Used
We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion contacts, achieving 1 kb resolution. We find that genomes are partitioned into contact domains (median length, 185 kb), which are associated with distinct patterns of histone… (More)
We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical structure of chromatin fibers, domains, and loops. We find that the observed contact domains are inconsistent with the equilibrium state for an ordinary… (More)
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X-ray crystal structure of the murine μOR bound to the morphinan agonist BU72 and a G protein mimetic camelid antibody fragment. The BU72-stabilized changes in the μOR… (More)
We prove a conjecture by Guo-Niu Han which interpolates between two known hook expansion formulas.
Evaluating the semantic similarity of two sentences is a task central to automated understanding of natural languages. We discuss the problem of semantic similarity and show that the use of recurrent and recursive neural networks can provide a 16% to 70% improvement over baseline models.
During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and adopts an unusual 3D configuration known as the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D conformation. We recently showed that in humans the Xi chromosome exhibits three structural features, two of which are not… (More)
GloVe is an algorithm which associates a vector to each word such that the dot product of two words corresponds to the likelihood they appear together in a large corpus ([PSM14]). GloVe vectors achieve state-of-the-art performance on word analogy tasks (v(king) − v(man) + v(woman) ≈ v(queen)), but they are limited to capturing meanings of individual words.… (More)