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  • Steven J Howe, Marc R Mansour, +24 authors Adrian J. Thrasher
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2008 (First Publication: 2 September 2008)
  • X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe the occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL)Expand
  • Christophe Demaison, Kathryn L. Parsley, +5 authors Adrian J. Thrasher
  • Medicine
  • Human gene therapy
  • 2002
  • Prolonged exposure of human hematopoietic stem cells (HSC) to growth factors for efficient transduction by murine oncoretroviral vectors has major detrimental effects on repopulating activity. InExpand
  • Adrian J. Thrasher, Christine Kinnon
  • Biology, Medicine
  • Clinical and experimental immunology
  • 2000 (First Publication: 1 April 2000)
  • The biological mechanisms responsible for the pathophysiology of the Wiskott–Aldrich syndrome (WAS) have been shown to be linked to the regulation of actin polymerization in haematopoietic cells. WASExpand