Adrian Gonzalez

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The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity and synapse loss. Here, we show that amyloid-β oligomers (AβOs) activate the c-Abl kinase in dendritic spines of cultured hippocampal neurons and that c-Abl kinase activity is required for AβOs-induced synaptic loss. We also show that the EphA4 receptor tyrosine kinase(More)
BACKGROUND Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate the ability of melatonin to regulate cyclooxygenases and assess whether the effects of(More)
Clustering aims at extracting hidden structures in datasets. Many validity indices have been proposed to evaluate clustering results; some of them work well when clusters have different densities and sizes and others with different shapes. They usually have a tendency to consider one or two characteristics simultaneously. In this paper, we present a cluster(More)
Melatonin exerts oncostatic effects on different kinds of neoplasias, especially on oestrogen-dependent tumours. Recently, it has been described that melatonin, on the basis of its antioxidant properties, inhibits the growth of glioma cells. Glioma cells express oestrogen receptors and have the ability to synthesise oestrogens from androgens. In the present(More)
In this article, I use Albert Hirschman's consumer-based 'exit' and 'voice' concepts in order to set out the political ecology of voice (PEV), an innovative theoretical framework that aims to examine the causes of environmental pollution from a new angle. I begin by providing a brief overview of political ecology, and why it provides such a useful framework(More)
This article focuses on the complex role that oil has played in many conflicts on the African continent. It begins by highlighting oil's influential role within war at a wider international level and provides a brief theoretical base from which to explore oil's role in the African continent. Then, the article provides evidence of petroleum's impact on(More)
Most pattern recognition applications within the Geoscience field involve the clustering and classification of remote sensed multispectral data, which basically aims to allocate the right class of ground category to a reflectance or radiance signal. Generally, the complexity of this problem is related to the incorporation of spatial characteristics that are(More)
  • Duggan De, Yeh Kc, Matalia N, Ditzler Ca, Mcmahon Fg Bioavailability, Hare Le +83 others
  • 2002
Dual uses of corticosteroids in treatment of cancer Adebodun F, Post JF. 19F NMR studies of changes in membrane potential and intracellular volume during dexamethasone-induced apoptosis in human leukemic cell lines. Glucocorticoid-induced apoptotic pathways in eosinophils: comparison with glucocorticoid-sensitive leukemia cells. apoptosis of human leukemic(More)
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