Adrian Derungs

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The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites. Each mutation in the MCR leads to the synthesis of a truncated APC product expressed in a colorectal tumour. The MCR(More)
In this work, we investigated whether activity routines of stroke rehabilitation patients can be discovered from body-worn motion sensor data and without data annotation using topic modeling. Information about the activity routines performed by stroke patients during daily life could add valuable information to personal therapy goals. As topic model input,(More)
BACKGROUND AND OBJECTIVE Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The objective of this study was to(More)
BACKGROUND Monitoring natural behavior and activity routines of hemiparetic rehabilitation patients across the day can provide valuable progress information for therapists and patients and contribute to an optimized rehabilitation process. In particular, continuous patient monitoring could add type, frequency and duration of daily life activity routines and(More)
We estimate the Extended Barthel Index (EBI) in patients after stroke using inertial sensor measurements acquired during daily activity, rather than specific assessments. The EBI is a standard clinical assessment showing patient independence in handling everyday tasks. Our work aims at providing a continuous ability estimate for patients and therapists that(More)
We present a motion-adaptive duty-cycling approach to estimate orientation using inertial sensors. In particular, we deploy a proportional forward-controller to adjust the duty-cycle of inertial sensing units (IMU) and the orientation estimation update rate of an extended Kalman filter (EKF). In sample data recordings and a simulated daily life dataset from(More)
Therapeutic drug monitoring of patients receiving once daily aminoglycoside therapy can be performed using pharmacokinetic (PK) formulas or Bayesian calculations. While these methods produced comparable results, their performance has never been checked against full PK profiles. We performed a PK study in order to compare both methods and to determine the(More)
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