Adrian Derungs

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The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are beta-catenin-binding sites. Each mutation in the MCR leads to the synthesis of a truncated APC product expressed in a colorectal tumour. The MCR(More)
We report a case of intoxication by the synthetic cannabinoid MAM-2201 ([1-(5-fluoropentyl)-1H-indol-3-yl](4-methyl-1-naphthalenyl)-methanone). A 31-year-old man smoked about 300 mg of a herbal blend. He experienced an acute transient psychotic state with agitation, aggression, anxiety, and vomiting associated with a sympathomimetic syndrome. MAM-2201 was(More)
CONTEXT Naphyrone (naphthylpyrovalerone) is a cathinone derivative and recreational drug related to mephedrone. CASE We report a 31-year-old man who ingested a dose of naphyrone (100 mg), which produced acute sympathomimetic toxicity with restlessness, insomnia, anxiety, and hallucinations lasting for 2 days. Naphyrone was detected in the patient's plasma(More)
BACKGROUND AND OBJECTIVE Phenotyping cocktails use a combination of cytochrome P450 (CYP)-specific probe drugs to simultaneously assess the activity of different CYP isoforms. To improve the clinical applicability of CYP phenotyping, the main objectives of this study were to develop a new cocktail based on probe drugs that are widely used in clinical(More)
In this work, we investigated whether activity routines of stroke rehabilitation patients can be discovered from bodyworn motion sensor data and without data annotation using topic modeling. Information about the activity routines performed by stroke patients during daily life could add valuable information to personal therapy goals. As topic model input,(More)
BACKGROUND AND OBJECTIVE Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The objective of this study was to(More)
BACKGROUND Monitoring natural behavior and activity routines of hemiparetic rehabilitation patients across the day can provide valuable progress information for therapists and patients and contribute to an optimized rehabilitation process. In particular, continuous patient monitoring could add type, frequency and duration of daily life activity routines and(More)
We report on a patient with Pneumocystis jirovecii pneumonia who developed fever, rash, eosinophilia and hepatitis 10 days after initiation of a therapy with sulfamethoxazole and trimethoprim. A DRESS syndrome was diagnosed and the therapy was changed successfully to pyrimethamine and dapsone. We describe the clinical picture, causative drugs, pathogenesis,(More)
Wir berichten über den Fall einer 63-jährigen Patientin mit unspezifischen rechtsseitigen Unterbauchbeschwerden, deren Abklärungsuntersuchungen zur Verdachtsdiagnose atherosklerotischer Aneurysmen sowohl der rechten als auch der linken A. iliaca communis führten. Dies wurde durch das Vorliegen kardiovaskulärer Risikofaktoren erhärtet. Während der(More)