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  • Jonathan Ledoux, Mark S. Taylor, +6 authors Mark T. Nelson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 15 July 2008)
  • Calcium (Ca2+) release through inositol 1,4,5-trisphosphate receptors (IP3Rs) regulates the function of virtually every mammalian cell. Unlike ryanodine receptors, which generate local Ca2+ eventsContinue Reading
  • Hélène Girouard, Adrian D. Bonev, Rachael M. Hannah, Andrea L Meredith, Richard W. Aldrich, Mark T. Nelson
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 23 February 2010)
  • Neuronal activity is thought to communicate to arterioles in the brain through astrocytic calcium (Ca2+) signaling to cause local vasodilation. Paradoxically, this communication may causeContinue Reading
  • Jonathan H Jaggar, G C Wellman, +10 authors Mark T. Nelson
  • Medicine, Chemistry
  • Acta physiologica Scandinavica
  • 1998 (First Publication: 1 December 1998)
  • Local calcium transients ('Ca2+ sparks') are thought to be elementary Ca2+ signals in heart, skeletal and smooth muscle cells. Ca2+ sparks result from the opening of a single, or the coordinatedContinue Reading
  • Guillermo J. Pérez, Adrian D. Bonev, Joseph B. Patlak, Mark T. Nelson
  • Chemistry, Medicine
  • The Journal of general physiology
  • 1999 (First Publication: 1 February 1999)
  • The relationship between Ca2+ release (“Ca2+ sparks”) through ryanodine-sensitive Ca2+ release channels in the sarcoplasmic reticulum and KCa channels was examined in smooth muscle cells from ratContinue Reading
  • Lydia W M Nausch, Jonathan Ledoux, Adrian D. Bonev, Mark T. Nelson, Wolfgang R G Dostmann
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 8 January 2008)
  • Here, we report the design of unprecedented, non-FRET based cGMP-biosensors, named FlincGs, to assess the dynamics of nitric oxide (NO) and atrial natriuretic peptide (ANP) induced synthesis ofContinue Reading