Adriaan Hofman

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Amyotrophic lateral sclerosis (ALS) is a late onset, rapidly progressive and ultimately fatal neurological disorder, caused by the loss of motor neurons in the brain and spinal cord. Familial aggregation of ALS, with an age-dependent but high penetrance, is a major risk factor for ALS. Familial ALS (FALS) is clinically and genetically heterogeneous. Three(More)
A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of(More)
  • A. Hofman
  • European Journal of Epidemiology
  • 1991
This paper describes a study of the risk of Creutzfeldt-Jakob disease in various European countries. The objectives of the study are to investigate the frequency of Creutzfeldt-Jakob disease and other human spongiform encephalophaties in Europe in relation to animal spongiform encephalophaties, and to assess the risk of Creutzfeldt-Jakob disease in relation(More)
  • A Hofman
  • The Netherlands journal of medicine
  • 1995
Epidemiology is concerned with the study of the frequency of disease occurrence. Clinical epidemiology is that part of epidemiology that deals with questions concerning clinical practice. Risk and prognosis are important concepts in clinical research and patient management . Risk of disease can be viewed as the chance, or the probability, that disease(More)
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