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Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
TLDR
In pregnancy, quinine continues to play a critical role in the management of malaria, especially in the first trimester, and it will remain a mainstay of treatment until safer alternatives become available. Expand
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial
TLDR
DP was superior to AL for reducing the risk of recurrent parasitemia and gametocytemia, and provided improved hemoglobin recovery, and appears to be a good alternative to AL as first-line treatment of uncomplicated malaria in Uganda. Expand
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treating Uncomplicated Malaria: A Randomized Trial to Guide Policy in Uganda
TLDR
Dihydroartemisinin-piperaquine is highly efficacious, and operationally preferable to AL because of a less intensive dosing schedule and requirements and should be considered for a role in the antimalarial treatment policy of Uganda. Expand
Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.
TLDR
There is no convincing evidence that the burden of malaria has decreased in Uganda in recent years, and major challenges to malaria control include very high malaria transmission intensity, inadequate health care resources, a weak health system, inadequate understanding of malaria epidemiology and the impact of control interventions, and inadequate epidemic preparedness and response. Expand
Artemisinin versus Nonartemisinin Combination Therapy for Uncomplicated Malaria: Randomized Clinical Trials from Four Sites in Uganda
TLDR
A AQ + AS was the most efficacious regimen for preventing recrudescence, but this benefit was outweighed by an increased risk of new infection. Expand
Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria in Uganda
TLDR
Artemether–lumefantrine was superior to amodiaquine + artesunate for prevention of new infections and frequent repeated therapy on the efficacy, safety, and cost-effectiveness of new artemisinin regimens should be further investigated. Expand
Estimating the annual entomological inoculation rate for Plasmodium falciparum transmitted by Anopheles gambiae s.l. using three sampling methods in three sites in Uganda
TLDR
In these settings, light traps provide an alternative method for sampling indoor-resting mosquitoes to human-landing catches and have the advantage that they protect individuals from being bitten during collection, are easy to use and are not subject to collector bias. Expand
Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis
TLDR
AS&AQ compares well to other treatments and meets the WHO efficacy criteria for use against falciparum malaria in many, but not all, the sub-Saharan African countries where it was studied. Expand
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
TLDR
The HIV-1 seroprevalence rate was surprisingly high in adults presenting with malaria, and this finding supports the implementation of routine HIV counseling and testing for adults with uncomplicated falciparum malaria. Expand
The effect of indoor residual spraying on malaria and anemia in a high-transmission area of northern Uganda.
TLDR
Carefully managed IRS can significantly reduce malaria burden in high-transmission settings, and a child living in a sprayed district had a 46% and 32% lower risk of parasitemia and anemia than a child in a non-sprayed district. Expand
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