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  • Renee J. Krause, Lawrence H. Lash, Adnan A. Elfarra
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2003 (First Publication: 1 January 2003)
  • The potential roles of human hepatic and renal flavin-containing monooxygenases (FMOs) in the metabolism of the cysteineS-conjugates S-allyl cysteine (SAC) andS-(1,2-dichlorovinyl)-l-cysteine (DCVC)Continue Reading
  • Renee J. Krause, Adnan A. Elfarra
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1997
  • Butadiene monoxide (BM) can be oxidized by cDNA-expressed human cytochrome P450 enzymes and by mouse, rat, and human liver microsomes to yield meso- and (+/-)-diepoxybutane (DEB). The DEBContinue Reading
  • Renee J. Krause, Steven C Glocke, Anna Rita Sicuri, Sharon L. Ripp, Adnan A. Elfarra
  • Chemistry, Medicine
  • Chemical research in toxicology
  • 2006 (First Publication: 1 December 2006)
  • The roles of flavin-containing monooxygenases (FMOs) in the oxidation of seleno-l-methionine (SeMet) to l-methionine selenoxide (MetSeO) were investigated using cDNA-expressed human FMOs, purifiedContinue Reading
  • Sjofn Gunnarsdottir, Adnan A. Elfarra
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1999 (First Publication: 1 September 1999)
  • cis-3-(9H-Purin-6-ylthio)acrylic acid (PTA) is a structural analog of azathioprine, a prodrug of the antitumor and immunosuppressive drug 6-mercaptopurine (6-MP). In this study, we examined the inContinue Reading
  • Sharon L. Ripp, Linwood H. Overby, Richard M. Philpot, Adnan A. Elfarra
  • Chemistry, Medicine
  • Molecular pharmacology
  • 1997 (First Publication: 1 March 1997)
  • Rabbit liver microsomes catalyzed the highly stereoselective, NADPH- and time-dependent S-oxidation of S-benzyl-L-cysteine (SBC), S-allyl-L-cysteine (SAC), S-(1,2-dichlorovinyl)-L-cysteine (DCVC),Continue Reading
  • Renee J. Krause, Steven C Glocke, Adnan A. Elfarra
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2002 (First Publication: 1 October 2002)
  • S-Allyl-L-cysteine (SAC), a component of garlic and a metabolite of allyl halides, is a known substrate for multiple flavin-containing monooxygenases (FMOs). In the current study, we characterize theContinue Reading
  • Renee J. Krause, J E Sharer, Adnan A. Elfarra
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1997 (First Publication: 1 August 1997)
  • Incubations of butadiene monoxide (BMO) with mouse, rat, and human liver microsomes or cDNA-expressed human microsomal epoxide hydrolase led to 3-buten-1,2-diol (BDD) detection; the BDD peakContinue Reading
  • Lawrence H. Lash, Wenjuan Qian, +4 authors James C. Parker
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2001 (First Publication: 1 April 2001)
  • Acute cytotoxicity (lactate dehydrogenase release) of trichloroethylene (TRI), S-(1,2-dichlorovinyl)glutathione (DCVG), and S-(1,2-dichlorovinyl)-L-cysteine (DCVC) in freshly isolated renal corticalContinue Reading