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Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2
Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. In the absence of any antiviral orExpand
Prediction of Functional Loss of Human Angiogenin Mutants Associated with ALS by Molecular Dynamics Simulations
Several missense mutations in the coding region of angiogenin (ANG) gene have been identified in Amyotrophic Lateral Sclerosis (ALS) patients. These mutations lead to loss of either ribonucleolyticExpand
Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis
Background Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss ofExpand
Development of multi-epitope driven subunit vaccine against Fasciola gigantica using immunoinformatics approach.
Fascioliasis, a serious helminth disease of the livestock population, results from infection with the parasite Fasciola. Despite the alarming increase in drug resistance, a safe and fully effectiveExpand
Computational and Functional Characterization of Angiogenin Mutations, and Correlation with Amyotrophic Lateral Sclerosis
The Angiogenin (ANG) gene is frequently mutated in patients suffering from the neurodegenerative disease - amyotrophic lateral sclerosis (ALS). Most of the ALS-causing mutations in Angiogenin affectExpand
Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis
Mutations in certain genes of the Ribonuclease (RNASE) superfamily can cause amyotrophic lateral sclerosis (ALS) through altered RNA processing mechanisms. About 30 of these missense mutations inExpand
High Throughput Designing and Mutational Mapping of RBD-ACE2 Interface Guide Non-Conventional Therapeutic Strategies for COVID-19
Considering the current status of the SARS-CoV-2 pandemic, sequence variations and possibly structural changes in the rapidly evolving SARS-CoV-2 is highly expected in the coming months. TheExpand
The VP4 Peptide of Hepatitis A Virus Ruptures Membranes through Formation of Discrete Pores
ABSTRACT Membrane-active peptides, components of capsid structural proteins, assist viruses in overcoming the host membrane barrier in the initial stages of infection. Several such peptides have beenExpand
Fast prediction of deleterious angiogenin mutations causing amyotrophic lateral sclerosis
Certain single nucleotide polymorphisms causing missense mutations in angiogenin result in its loss‐of‐function and onset of amyotrophic lateral sclerosis (ALS). Although several such associationsExpand
NeuroDNet - an open source platform for constructing and analyzing neurodegenerative disease networks
BackgroundGenetic networks control cellular functions. Aberrations in normal cellular function are caused by mutations in genes that disrupt the fine tuning of genetic networks and cause disease orExpand