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Early-onset Alzheimer's disease (EOAD) beginning before the age of 65 may differ from late-onset AD (LOAD) in clinical course and frequency of nonamnestic presentations. In a 10-year retrospective review, 125 patients with EOAD, diagnosed clinically and verified by functional neuroimaging, were compared with 56 patients with LOAD and further classified(More)
OBJECTIVE To characterize the presenting symptoms and signs of patients clinically diagnosed with behavioral variant frontotemporal dementia (bvFTD) and who had different neuropathologic findings on autopsy. METHODS This study reviewed all patients entered as clinical bvFTD in the National Alzheimer's Coordinating Center's database and who had both(More)
OBJECTIVE To quantify myocardial iron stores by Cardiac Magnetic Resonance (CMR). DESIGN Prospective cohort study. SETTING Thalassemia center in a teaching hospital. PARTICIPANTS 60 transfusion dependant thalassemia major patients and 10 controls during 2008-2009. METHODS MRI T2* for cardiac iron load and cardiac functions was performed on a 1.5(More)
Although familial Alzheimer’s disease (FAD) is an early onset AD (EAD), most patients with EAD do not have a familial disorder. Recent guidelines recommend testing for genes causing FAD only in those EAD patients with two first-degree relatives. However, some patients with FAD may lack a known family history or other indications for suspecting FAD but might(More)
Emotional blunting is a core diagnostic feature of behavioral variant frontotemporal dementia (bvFTD). The authors evaluated skin conductance as a measure of emotional blunting among 10 patients with bvFTD compared with 10 with Alzheimer's disease and 14 healthy control subjects. Despite responses to an auditory startle stimulus, skin conductance levels(More)
BACKGROUND Schizophrenia is associated with impaired face processing. N170 and N250 are two event-related potentials that have been studied in relation to face processing in schizophrenia, but the results have been mixed. The aim of this article was to conduct a meta-analysis of N170 and N250 in schizophrenia to evaluate trends and resolve the(More)
Early social dysfunction is a hallmark symptom of behavioral variant frontotemporal dementia (bvFTD); however, validated measures for assessing social deficits in dementia are needed. The purpose of the current study was to examine the utility of a novel informant-based measure of social impairment, the Socioemotional Dysfunction Scale (SDS) in early-onset(More)
BACKGROUND Resting sympathetic tone, a measure of physiological arousal, is decreased in patients with apathy and inertia, such as those with behavioral variant frontotemporal dementia (bvFTD) and other frontally-predominant disorders. OBJECTIVE To identify the neuroanatomical correlates of skin conductance levels (SCLs), an index of resting sympathetic(More)
BACKGROUND Emotional blunting is a major clinical feature of behavioral variant frontotemporal dementia (bvFTD). Assessing the change in emotional blunting may facilitate the differential diagnosis of this disorder and can quantify a major source of distress for the patients' caregivers and families. METHODS We evaluated investigator ratings on the Scale(More)