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Severity grading of psoriatic plaques using deep CNN based multi-task learning
TLDR
A novel deep CNN based architecture for achieving the problem of automatic machine analysis based severity scoring of psoriasis skin disease is presented and shows that the deepCNN based architectures (both the STL and MTL) achieve promising performances. Expand
Genetic and epigenetic basis of psoriasis pathogenesis.
TLDR
The present knowledge of epigenetic involvement, mainly the DNA methylation, chromatin modifications and miRNA deregulation is surveyed and an integrated approach considering genetic and epigenetic anomalies in the light of immunological network may explore the pathogenesis of psoriasis. Expand
Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis
TLDR
This study indicated the possible involvement of DNA methylation in regulating the cardinal pathophysiological features in psoriasis for the first time. Expand
Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population
TLDR
Integration of genetic and gene expression data allowed us to identify the actual disease variants at the LCE3 cluster among the psoriasis patients in India. Expand
Genome-wide DNA methylation profile identified a unique set of differentially methylated immune genes in oral squamous cell carcinoma patients in India
TLDR
This study identified a unique set of hypomethylated regions, enriched in the promoters of immune response genes, and indicated the presence of a strong immune component in the tumor microenvironment. Expand
Localized TWIST1 and TWIST2 basic domain substitutions cause four distinct human diseases that can be modeled in Caenorhabditis elegans
TLDR
A new clinical entity is described, Sweeney-Cox syndrome, associated with distinct de novo amino acid substitutions at a highly conserved glutamic acid residue located in the basic DNA binding domain of TWIST1, in two subjects with frontonasal dysplasia and additional malformations. Expand
Associations of ERAP1 coding variants and domain specific interaction with HLA-C∗06 in the early onset psoriasis patients of India.
TLDR
Investigation of the association and possible functional role of non-synonymous SNPs at different exons of ERAP1 and their interactions with HLA-C∗06 in psoriasis showed confinement of Lys528 and Gln730 within highly conserved regions of ER AP1 and suggested the possible detrimental effect of this allele inERAP1 regulation. Expand
Psoriasis skin biopsy image segmentation using Deep Convolutional Neural Network
TLDR
The present research shows that practical system can be developed for machine assisted analysis of psoriasis disease and the CNN based approaches outperform the traditional hand-crafted feature based classification approaches. Expand
CR2Cancer: a database for chromatin regulators in human cancer
TLDR
A comprehensive annotation and visualization database for CRs in human cancer constructed by high throughput data analysis and literature mining, it is believed that this database would become a valuable resource for cancer epigenetics investigation and potential clinical application. Expand
Association of IL12B risk haplotype and lack of interaction with HLA-Cw6 among the psoriasis patients in India
TLDR
The data suggested the association of IL 12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psOriasis patients in India. Expand
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