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This article proposes the image intraclass correlation (I2C2) coefficient as a global measure of reliability for imaging studies. The I2C2 generalizes the classic intraclass correlation (ICC) coefficient to the case when the data of interest are images, thereby providing a measure that is both intuitive and convenient. Drawing a connection with classical(More)
Peer-to-peer systems have emerged as a robust, scalable and decentralized way to share and publish data. In this paper, we propose P-Ring, a new P2P index structure that supports both equality and range queries. P-Ring is fault-tolerant, provides logarithmic search performance even for highly skewed data distributions and efficiently supports large sets of(More)
Current peer-to-peer (P2P) index structures only support a subset of the desired functionality for P2P database systems. For instance, some P2P index structures support equality queries but not range queries, while others support range queries, but do not support multiple data items per peer or provide guaranteed search performance. In this paper , we(More)
In peer-to-peer (P2P) systems, computers from around the globe share data and can participate in distributed computation. P2P became famous, and infamous, due to file-sharing systems like Napster. However, the scalability and robustness of these systems make them appealing to a wide range of applications. This article introduces P-Ring, a new peer-to-peer(More)
Bloom filters are probabilistic data structures commonly used for approximate membership problems in many areas of Computer Science (networking, distributed systems, databases, etc.). With the increase in data size and distribution of data, problems arise where a large number of Bloom filters are available, and all them need to be searched for potential(More)
Resource Description Framework (RDF) was designed with the initial goal of developing metadata for the Internet. While the Internet is a conglomeration of many interconnected networks and computers, most of today's best RDF storage solutions are confined to a single node. Working on a single node has significant scalability issues, especially considering(More)
New and emerging P2P applications require sophisticated range query capability and also have strict requirements on query correctness, system availability and item availability. While there has been recent work on developing new P2P range indices, none of these indices guarantee correctness and availability. In this paper, we develop new techniques that can(More)
We propose a novel statistical model and inferential algorithm for gene environment interaction. Our methodology was motivated by and applied to identity by descent (IBD) sharing for sibling pairs affected by schizophrenia. Our analysis confirms some of the previous findings on the same data set, e.g. the estimated location of the disease gene and the(More)