Adhikari L Reddy

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The discovery of a two-stage mechanism of carcinogenesis in mouse skin, with initiation and promotion as independent components, provided new approaches to the study of the development of neoplasms in experimental animals and humans. However, it is not clear how the carcinogen and promoting agent are involved at different steps in the development of(More)
The cellular origin of tumors induced by the chemical carcinogen 3-methylcholanthrene (MCA) was studied in mice with X-chromosome inactivation mosaicism. Because only one of the two X-chromosomes is active in XX somatic cells, a female heterozygous at the X-linked phosphoglycerate kinase (PGK-1) locus for the usual Pgk-1b gene and the variant Pgk-1a has two(More)
We examined the effects of initiation with different doses of 7,12-dimethylbenz[a]anthracene (DMBA) on two-stage skin carcinogenesis in BALB/c mice. The induction of skin papillomas and their sequential tumor progression were followed by determination of locations of the tumors on the back of each mouse, by histological evaluation and by determining the(More)
The glucose-6-phosphate dehydrogenase (G.-6-P.D.) types of isolated blood-cell populations and normal skin were determined in two patients with chronic lymphocytic leukaemia (C.L.L.) who were heterozygous at the G.-6-P.D. locus. Normal tissues from each patient manifested both A and B G.-6-P.D. types, but the C.L.L. B-lymphocyte preparation from one patient(More)
The induction of mouse skin papillomas in two stages by initiation-promotion protocols has been studied extensively. On the basis of kinetics of induction and morphological observations of apparent progression to carcinomas, it has been argued that the papillomas sequentially advance to carcinomas through promoter-dependent and promoter-independent(More)
Most mouse skin papillomas induced by 7,12-dimethylbenz(a)-anthracene initiation followed by 12-O-tetradecanoylphorbol-13 acetate (TPA) promotion are benign promoter-dependent papillomas which regress after cessation of promotion, but some benign tumors (promoter-independent papillomas) do not regress, and a few carcinomas seem to develop from progressive(More)
We have shown previously, with X-chromosome linked phosphoglycerate kinase (PGK) cell markers, that the fibrosarcomas induced in mice by subcutaneous injection of 0.2-2.0 mg of methylcholanthrene (MCA) dissolved in olive oil had a multicellular origin. In this study we used a constant dose of MCA injected subcutaneously and compared the effects on(More)
Repeated promotion of 7,12-dimethylbenz[alpha]anthracene-initiated cells in mouse skin with 12-O-tetradecanoylphorbol-13-acetate (TPA) induces them to grow as premalignant skin papillomas and some of these subsequently progress to carcinomas. In this study, we demonstrate that this TPA-induced progression of initiated cells to papillomas and carcinomas(More)
The number of cells from which tumors induced by subcutaneous implantation of foreign bodies develop was studied in BALB/c mice with X-chromosome-inactivation mosaicism. Because only one of the two X-chromosomes is active in XX somatic cells, a female mouse heterozygous at the X-linked phosphoglycerate kinase (PGK) locus for Pgk-1b and Pgk-1a has two types(More)