Adeline Rollin-Sillaire

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There are many reports of cognitive dysfunction in patients receiving chemotherapy or targeted therapies. Many antineoplastic agents may be involved in the condition also known as “chemo brain” or “chemo fog”. Two male patients (aged 41 and 70) with multiple myeloma developed severe, rapidly progressing cognitive impairment (mostly involving episodic(More)
OBJECTIVE To study the association between ABCA7 rare coding variants and Alzheimer disease (AD) in a case-control setting. METHODS We conducted a whole exome analysis among 484 French patients with early-onset AD and 590 ethnically matched controls. RESULTS After collapsing rare variants (minor allele frequency ≤1%), we detected an enrichment of ABCA7(More)
OBJECTIVE To assess seizure frequency in a large French cohort of autosomal dominant early-onset Alzheimer disease (ADEOAD) and to determine possible correlations with causative mutations. METHODS A national multicentric study was performed in patients with ADEOAD harboring a pathogenic mutation within PSEN1, PSEN2, APP, or a duplication of APP, and a(More)
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