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In this study, the direct actions of serotonin (5HT) on gonadotropin (GTH)-II and growth hormone (GH) release in the goldfish were tested at the pituitary cell level. 5HT (10 nM - 10 µM) stimulated GTH-II but inhibited GH release from perifused goldfish pituitary cells in a dose-dependent manner. The minimal effective dose of 5HT tested to suppress basal GH(More)
Thus far, genome-wide association studies (GWAS) have been disappointing in the inability of investigators to use the results of identified, statistically significant variants in complex diseases to make predictions useful for personalized medicine. Why are significant variables not leading to good prediction of outcomes? We point out that this problem is(More)
The ultrasonographic (US) appearance of a syringocoele of the bulbourethral (Cowper) duct, with correlative urethrocystoscopic images, is demonstrated. An infant boy, 5 weeks of age, who presented with E. coli infection of the urinary tract also had bilateral hydroureteronephrosis, small bilateral simple ureterocoeles, and posterior urethral valve leaflets.
We propose a new method for identifying disease-related regions of single nucleotide variants in recently admixed populations. We use principal component analysis to derive both global and local ancestry information. We then use the summation partition approach to search for disease-related regions based on both rare variants and the local ancestral(More)
Matching is a popular technique for preprocessing observational data to facilitate causal inference and reduce model dependence by ensuring that treated and control units are balanced along pre-treatment covariates. While most applications of matching balance on a small number of covariates, we identify situations where matching with thousands of covariates(More)
We propose approaching prediction from a framework grounded in maximizing correct prediction rates. While this is intuitively obvious, not nearly enough attention has been paid to the creation of a clear theoretical framework for prediction; motivated by the needs of current genome-wise association studies (GWAS) we provide a discussion on such a framework.(More)
A vast literature on international trade predicts that political institutions affect both the choice of trade partners (extensive margin) and trade volumes (intensive margin). Yet most analyses ignore the former margin, while their estimates of the latter neglect nontrading pairs and thereby suffer from selection bias. Also, the data on individual features(More)
The primary hyperoxalurias are a set of rare autosomal recessive disorders of inborn errors of metabolism resulting in endogenous overproduction of oxalate. A 16 year old girl with chronic kidney disease stage IV was transferred for further care to the adult nephrology clinic. She had undergone a right sided pyelolithotomy at the age of 8 years. The(More)
Interactions between genes are an important part of the genetic architecture of complex diseases. In this paper, we use literature-guided individual genes known to be associated with type 2 diabetes (referred to as "seed genes") to create a larger list of genes that share implied or direct networks with these seed genes. This larger list of genes are known(More)
The mass killing of 20 children and 6 adults on 14 December 2012 at Sandy Hook Elementary School in Newtown, Connecticut (Fig. 1), has revived an enduring controversy about gun control in the United States. Gun-control advocates believe that widespread gun ownership increases the rate of gun-related crime and homicide, whereas critics argue that gun(More)