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Thus far, genome-wide association studies (GWAS) have been disappointing in the inability of investigators to use the results of identified, statistically significant variants in complex diseases to make predictions useful for personalized medicine. Why are significant variables not leading to good prediction of outcomes? We point out that this problem is(More)
The ultrasonographic (US) appearance of a syringocoele of the bulbourethral (Cowper) duct, with correlative urethrocystoscopic images, is demonstrated. An infant boy, 5 weeks of age, who presented with E. coli infection of the urinary tract also had bilateral hydroureteronephrosis, small bilateral simple ureterocoeles, and posterior urethral valve leaflets.
We propose a new method for identifying disease-related regions of single nucleotide variants in recently admixed populations. We use principal component analysis to derive both global and local ancestry information. We then use the summation partition approach to search for disease-related regions based on both rare variants and the local ancestral(More)
We propose approaching prediction from a framework grounded in maximizing correct prediction rates. While this is intuitively obvious, not nearly enough attention has been paid to the creation of a clear theoretical framework for prediction; motivated by the needs of current genome-wise association studies (GWAS) we provide a discussion on such a framework.(More)
Roemer’s theory of equality of opportunity (EOp) makes a crucial distinction between fair and unfair inequalities, based on the assumption that groups experiencing unfair forms of inequality should be compensated. We argue that when there are insufficient resources to fully compensate groups or individuals for existing unfair inequalities — a very real(More)
A mathematical model of gun ownership has been developed that clarifies the debate on gun control and tentatively suggests that firearms restrictions may reduce the homicide rate. T he mass killing of 20 children and 6 adults on 14 December 2012 at Sandy Hook Elementary School in Newtown, Connecticut (Fig. 1), has revived an enduring controversy about gun(More)
Interactions between genes are an important part of the genetic architecture of complex diseases. In this paper, we use literature-guided individual genes known to be associated with type 2 diabetes (referred to as "seed genes") to create a larger list of genes that share implied or direct networks with these seed genes. This larger list of genes are known(More)
We propose approaching prediction from a framework grounded in the theoretical correct prediction rate of a variable set as a parameter of interest. This framework allows us to define a measure of predictivity that enables assessing variable sets for, preferably high, predictivity. We first define the prediction rate for a variable set and consider, and(More)
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