Adelbert Grossmann

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Ion-exchange chromatography is used in biopharmaceutical downstream processes to reduce product-related impurity levels. Because protein aggregate levels can be considered as a critical quality attribute, the removal of aggregated protein species is of primary importance. The addition of polyethylene glycol (PEG) to the mobile phase in ion-exchange(More)
Methods are described for the detection of potato virus X (PVX) by reverse passive haemagglutination (RPH) by means of polyclonal antiviral antibodies coupled to sheep red blood cells (sRBC) and the chromic chloride method. The cells were stabilized with pyruvic aldehyde, thus providing a stock suspension for numerous coupling experiments lasting several(More)
T HAS BEEN OUR EXPERIENCE (1) that accurate measurement on large numbers of samples in a minimum amount of working time per specimen can be achieved consistently in the analysis of protein-bound iodine by means of alkaline incineration. However, with the use of incineration, where many samples may be exposed simultaneously in enclosed spaces such as(More)
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