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Divergence and Mosaicism among Virulent Soil Phages of the Burkholderia cepacia Complex
TLDR
While head and tail morphogenesis genes have retained canonical gene order despite extreme sequence divergence, genes involved in DNA metabolism and host lysis are not organized as in other phages, which may contribute to the ability of the Bcep781-like phages to maintain a unified genomic type.
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence
TLDR
This study demonstrates that genes within RD8, 9 and 13 also contribute to virulence, which indicates that genesWithin these loci are necessary for spread of the bacteria beyond the nasopharynx to normally sterile sites.
Similar Biophysical Abnormalities in Glomeruli and Podocytes from Two Distinct Models.
TLDR
The severe defects in podocyte mechanical behavior in the Tg26 model may explain why Tg 26 glomeruli soften progressively, despite increased collagen deposition, and may be the basis for the rapid course of glomerular diseases associated with severe podocyte injury.
Biochemical and Cellular Determinants of Renal Glomerular Elasticity
TLDR
The reduction in glomerular E following ischemia and in other diseases indicates that reduced glomersular E is a common feature of many forms of glomerULAR injury and indicative of an abnormal podocyte cytoskeleton.
Vaccinia Virus A6L Encodes a Virion Core Protein Required for Formation of Mature Virion
TLDR
A recombinant vaccinia virus encoding A6 with an epitope tag was constructed and it was shown that A6 was expressed in infected cells after viral DNA replication and packaged in the core of the mature virion.
Vaccinia Virus A6 Is Essential for Virion Membrane Biogenesis and Localization of Virion Membrane Proteins to Sites of Virion Assembly
TLDR
Results show that A6 is an additional VACV protein that participates in an early step of virion membrane biogenesis, suggesting that MV membrane proteins or precursors of MV membranes are trafficked to sites of virions assembly through an active, virus-mediated process that requires A6.
Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse.
TLDR
The data show that recurrent tumors-across histologies and primary treatments-express distinct antigens compared with the primary tumor which can be identified using the VSV-cDNA library technology, and suggest that it may be possible to design a few common second-line therapies against a variety of tumor recurrences, in some cases using agents with no obvious activity against thePrimary tumor.
Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase
TLDR
The importance of WNK1 in regulation of the podocyte actin cytoskeleton, biophysical properties of glomerular capillaries, and slit diaphragm structure, all of which are essential to normal kidney function are demonstrated.
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