Adarsh J. Sai

Learn More
BACKGROUND Serum 25-hydroxyvitamin D (25-[OH]D) is considered the best biomarker of clinical vitamin D status. OBJECTIVE To determine the effect of increasing oral doses of vitamin D(3) on serum 25-(OH)D and serum parathyroid hormone (PTH) levels in postmenopausal white women with vitamin D insufficiency (defined as a 25-[OH]D level ≤50 nmol/L) in the(More)
Osteoporosis is a major public health problem for adults over age 55 years costing billions of euros/dollars. Over the last 20 years anti-resorptive drugs were the treatment of choice for osteoporosis and most were derived from the bisphosphonate molecule. In the last 7 years remarkable advances in molecular biology and genetics have led to a detailed(More)
OBJECTIVES To ascertain the risk factors for falls, stumbles and recurrent falls in a cohort of elderly people with mean age of 76.7-/+6.1 years. METHODS 137 community dwelling elderly living independently or in assisted living institutions participated in the study. Each subject was assessed by history, physical examination and physical performance tests(More)
CONTEXT There is a controversy regarding the definition of vitamin D insufficiency as it relates to bone health. OBJECTIVE The objective of the study was to examine the evidence for a threshold value of serum 25-hydroxyvitamin D (25OHD) that defines vitamin D insufficiency as it relates to bone health. DESIGN AND PARTICIPANTS This was a cross-sectional(More)
There has been increasing interest in the potential benefits of vitamin D. Much of the stimulus came from meta-analysis of vitamin D and calcium in osteoporotic fracture studies as well as association studies relating increased prevalence of diseases such as cancer, diabetes, multiple sclerosis, and cardiovascular events with lower levels of serum(More)
OBJECTIVE The aim of this study was to examine the effect of conjugated equine estrogens alone (ET), conjugated equine estrogens + medroxyprogesterone (EPT), calcitriol alone, calcitriol + EPT/ET, or placebo on serum lipid profile and analyze the interaction with estrogen receptor-α gene single nucleotide polymorphisms (ESR-α SNPs) on the response to(More)
intensive glucose lowering produced a statisti cally significant reduction in major cardiovascular disease outcomes without a significant increase in mortality. in all of these studies, the patients in the intensive therapy groups were treated with insulin. in conclusion, in the retrospective study by Currie et al., the between­cohort compari son was not(More)
  • 1