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The mini-chromosome maintenance (MCM) complex is the principal candidate for the replicative helicase of archaea and eukaryotes. Here, we describe a functional dissection of the roles of the three principal structural modules of the homomultimeric MCM of the hyperthermophilic archaeon Sulfolobus solfataricus. Our results include the first analysis of the(More)
The extracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovarian cancer cells. Paclitaxel-resistant cells treated with(More)
both primase and MCM helicase motifs together in one Eukaryotic/Archaeal Primase protein has not previously been described for archaea and MCM Proteins Encoded and eukaryotes. Interestingly, this modular nature is reminiscent of the T7 phage primase-helicase protein. However, the T7 primase and helicase domains are related to bacterial DnaG and DnaB,(More)
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